Sức khỏe sinh vật là gì? Các nghiên cứu khoa học liên quan

Định nghĩa Sức khỏe Sinh vật

Sức khỏe sinh vật (biological health) là trạng thái cân bằng nội tại và khả năng thích nghi, sinh trưởng, sinh sản của một cá thể hoặc quần thể sinh vật trong hệ sinh thái của nó. Khái niệm này không chỉ bao gồm các chức năng sinh lý cơ bản như trao đổi chất, sinh sản và phát triển, mà còn cả khả năng chống chịu với stress sinh học (nhiệt độ, nhiễm khuẩn) và phục hồi sau tổn thương.

Ở cấp độ cá thể, sức khỏe sinh vật thể hiện qua các chỉ tiêu như tỷ lệ sống, tốc độ tăng trưởng, khả năng sinh sản và năng lực phòng vệ miễn dịch. Ở cấp độ quần thể, cần đánh giá thêm các yếu tố như mật độ, cấu trúc tuổi và khả năng duy trì quần sự đa dạng di truyền. Việc duy trì sức khỏe sinh vật là yếu tố quyết định cho sự ổn định và bền vững của hệ sinh thái.

Khả năng duy trì năng suất sinh học và chu trình sinh địa hóa phụ thuộc trực tiếp vào sức khỏe của các loài chủ chốt (keystone species) và quần xã vi sinh vật đất – nước. Khi một hoặc nhiều loài quan trọng bị suy giảm sức khỏe, Trung tâm Điều phối Một Sức khỏe (One Health) nhấn mạnh hệ quả lan rộng đến sức khỏe con người và vật nuôi (WHO One Health).

Phạm vi và Tầm quan trọng

Phạm vi của sức khỏe sinh vật bao gồm từ cấp độ phân tử (sinh hóa, di truyền) đến cấp độ sinh thái (mối tương tác giữa sinh vật và môi trường). Mỗi cấp độ có những chỉ số và tiêu chuẩn đánh giá riêng, tuy nhiên mục tiêu chung là đảm bảo chức năng sinh trưởng, sinh sản và duy trì quần thể qua các điều kiện biến động.

Vai trò của sức khỏe sinh vật đặc biệt nổi bật trong lĩnh vực nông nghiệp, chăn nuôi và nuôi trồng thủy sản, nơi năng suất sản phẩm gắn liền với khả năng kháng bệnh và tăng trưởng tối ưu của vật nuôi hoặc cây trồng. Đồng thời, trong bảo tồn đa dạng sinh học, sức khỏe sinh vật giúp dự báo nguy cơ tuyệt chủng và đề xuất biện pháp phục hồi quần xã.

• An ninh lương thực: đảm bảo nguồn cung thực phẩm ổn định, giảm thiểu thất thoát do dịch bệnh;
• Sức khỏe cộng đồng: ngăn ngừa bệnh truyền zoonotic (qua động vật sang người);
• Bảo tồn hệ sinh thái: giảm thiểu mất cân bằng chu trình dinh dưỡng và giảm ô nhiễm môi trường.

Liên minh Nông Lương Liên Hiệp Quốc (FAO) coi định hướng nâng cao sức khỏe sinh vật là chìa khóa cho phát triển nông nghiệp bền vững và thích ứng với biến đổi khí hậu (FAO Biological Control).

Các Yếu tố Ảnh hưởng

Yếu tố sinh học: mầm bệnh (virus, vi khuẩn, ký sinh trùng), vi sinh vật cộng sinh và các loài đối kháng. Sự cân bằng giữa hệ vi sinh vật có lợi và có hại quyết định phần lớn khả năng đề kháng và phục hồi của sinh vật chủ.

Yếu tố môi trường: bao gồm điều kiện nhiệt độ, độ ẩm, pH, độ oxy hoà tan trong nước và mức độ ô nhiễm hoá chất (kim loại nặng, thuốc trừ sâu). Ví dụ, nhiệt độ nước nuôi trồng thủy sản từ 25–30 °C thường tối ưu cho ấu trùng phát triển, trong khi ô nhiễm hữu cơ cao làm giảm độ oxy và gia tăng stress sinh học.

Yếu tố di truyền và dinh dưỡng: tính thích nghi di truyền quyết định khả năng chịu hạn, chịu nóng hoặc kháng bệnh; dinh dưỡng đầy đủ (đạm, khoáng chất, vitamin) đảm bảo hệ miễn dịch hoạt động hiệu quả. Sự tương tác giữa genotype và môi trường (G×E) là chìa khóa để chọn giống và tối ưu hóa chế độ nuôi dưỡng.

Chỉ số và Đơn vị Đo lường

Các chỉ số thường dùng để đánh giá sức khỏe sinh vật bao gồm:

• Tỷ lệ sống (Survival Rate, SR): tỷ lệ phần trăm cá thể còn sống sau một khoảng thời gian xác định;
• Tốc độ tăng trưởng khối lượng trung bình hàng ngày (Average Daily Gain, ADG): đo hiệu quả dinh dưỡng và năng suất sinh khối;
• Chỉ số kháng bệnh (Disease Resistance Index, DRI): phản ánh khả năng sinh vật chủ chống chịu với mầm bệnh.

$DRI = \frac{1}{n}\sum_{i=1}^n \frac{S_i - C_i}{C_i}$

Trong đó S_i là tỷ lệ sống ở nhóm thử nghiệm, C_i là tỷ lệ sống ở nhóm đối chứng, và n là số đợt thử nghiệm. Giá trị DRI càng cao chứng tỏ mức độ kháng bệnh càng mạnh.

Chỉ số	Công thức/Tính toán	Ứng dụng
SR	$SR = \frac{N_{alive}}{N_{total}} \times 100\%$	Đánh giá khả năng sống sót
ADG	ADG = \frac{W_{final} - W_{initial}}{T}\end{script>	Đo hiệu suất tăng trưởng
DRI	$1/n \sum (S_i-C_i)/C_i</span></td> <td>Đánh giá kháng bệnh</td> </tr> </tbody> </table> <p>Việc sử dụng đồng bộ nhiều chỉ số giúp cung cấp cái nhìn toàn diện về sức khỏe sinh vật, từ đó đề xuất biện pháp cải thiện và quản lý bền vững.</p> <h2>Tương tác Vật chủ – Mầm bệnh</h2> <p>Quá trình tương tác giữa sinh vật chủ và mầm bệnh quyết định kết quả cuối cùng của nhiễm trùng, bao gồm xâm nhập, nhân lên và lan truyền. Mầm bệnh có thể là virus, vi khuẩn, ký sinh trùng hoặc nấm, mỗi loại sở hữu cơ chế xâm lấn và độc lực khác nhau. Ví dụ, vi khuẩn gây bệnh đường ruột tiết độc tố làm băng hoại biểu mô, trong khi virus xâm nhập tế bào rồi sử dụng bộ máy di truyền của chủ để sinh sản.</p> <p>Độc lực của mầm bệnh (virulence) được định lượng qua chỉ số LD<sub>50</sub> (liều gây chết 50% quần thể thí nghiệm) hoặc ID<sub>50</sub> (liều lây nhiễm cho 50%). Mức độ độc lực càng cao thì khả năng gây tổn thương và tỷ lệ tử vong của vật chủ càng lớn. Đồng thời, khả năng né tránh hệ miễn dịch của mầm bệnh—ví dụ như lớp vỏ polysaccharide của một số vi khuẩn—giúp tăng cường khả năng tồn tại và truyền bệnh.</p> <p>Cân bằng mối quan hệ “vũ khí và lá chắn” giữa mầm bệnh và vật chủ quyết định diễn biến bệnh: nếu hệ miễn dịch mạnh, mầm bệnh sẽ bị kiểm soát; ngược lại, mầm bệnh vượt qua hàng rào bảo vệ sẽ gây bệnh nghiêm trọng. Nghiên cứu mô hình in vitro (nuôi cấy tế bào) và in vivo (động vật thí nghiệm) là công cụ quan trọng để đánh giá cơ chế tương tác và tìm kiếm kháng sinh, kháng thể trung hòa hiệu quả (<a href="https://www.cdc.gov/animalimportation/animal_health.html" target="_blank">CDC Animal Health</a>).</p> <h2>Hệ miễn dịch và Đề kháng</h2> <p>Hệ miễn dịch vật chủ bao gồm miễn dịch bẩm sinh và miễn dịch thu được, phối hợp chặt chẽ để phát hiện và tiêu diệt mầm bệnh. Miễn dịch bẩm sinh khởi phát nhanh chóng nhờ đại thực bào, tế bào đuôi gai và protein bổ thể; cơ chế này không đặc hiệu nhưng tạo hàng rào bảo vệ ban đầu.</p> <p>Miễn dịch thu được phát triển chậm hơn nhưng có tính đặc hiệu cao, dựa trên tế bào B sản xuất kháng thể và tế bào T tiêu diệt. Kháng thể gắn kết kháng nguyên trên bề mặt mầm bệnh, kích hoạt bổ thể hoặc trung hòa trực tiếp. Tế bào T CD8+ nhận diện và tiêu diệt tế bào bị nhiễm, trong khi tế bào T CD4+ hỗ trợ quá trình sinh kháng thể và điều hòa phản ứng viêm.</p> <ol> <li><strong>Miễn dịch bẩm sinh:</strong> thông qua hàng rào vật lý (da, niêm mạc), thực bào và bổ thể.</li> <li><strong>Miễn dịch thu được:</strong> tế bào lympho T và B, kháng thể IgG, IgM, IgA.</li> <li><strong>Cơ chế điều hòa:</strong> cytokine, chemokine giám sát độ mạnh và thời gian của phản ứng viêm.</li> </ol> <p>Kháng kháng sinh và kháng kháng virus ngày càng gia tăng do chọn lọc từ lạm dụng thuốc. Giải pháp gồm phát triển kháng sinh mới, sử dụng phage therapy và điều chỉnh chế độ điều trị để giảm áp lực chọn lọc lên vi khuẩn (<a href="https://www.who.int/antimicrobial-resistance" target="_blank">WHO AMR</a>).</p> <h2>Tích hợp với Sức khỏe Hệ sinh thái</h2> <p>Mô hình One Health kết nối sức khỏe sinh vật, con người và môi trường, nhấn mạnh tính liên ngành và toàn diện. Khi một thành phần trong chuỗi – bao gồm động vật hoang dã, vật nuôi, vi sinh vật môi trường – bị ảnh hưởng, hệ sinh thái tổng thể trở nên mất cân bằng và tăng nguy cơ bùng phát dịch bệnh.</p> <p>Ví dụ, phá rừng làm thay đổi quần xã động vật, thúc đẩy sự tiếp xúc gần hơn giữa virus dơi và người, dẫn đến các ổ dịch mới. Đồng thời, ô nhiễm nước và đất ảnh hưởng đến quần xã vi sinh vật, làm giảm khả năng phân giải chất hữu cơ và gia tăng các mầm bệnh dạng ký sinh.</p> <table> <thead> <tr> <th>Thành phần</th> <th>Ảnh hưởng</th> <th>Giải pháp tích hợp</th> </tr> </thead> <tbody> <tr> <td>Động vật hoang dã</td> <td>Ổ chứa mầm bệnh</td> <td>Giám sát động vật, hạn chế tiếp xúc</td> </tr> <tr> <td>Vật nuôi</td> <td>Lây chéo zoonotic</td> <td>Tiêm phòng, quản lý chất thải</td> </tr> <tr> <td>Vi sinh vật môi trường</td> <td>Cân bằng vi sinh vật bị phá vỡ</td> <td>Quản lý ô nhiễm, phục hồi hệ vi sinh vật</td> </tr> </tbody> </table> <p>Tích hợp One Health đòi hỏi hợp tác giữa bác sĩ thú y, nhà dịch tễ học, môi trường học và chính sách công để xây dựng chương trình giám sát đa tầng và can thiệp kịp thời.</p> <h2>Phương pháp Giám sát và Đánh giá</h2> <p>Giám sát sức khỏe sinh vật dùng kết hợp phương pháp định tính và định lượng. Phương pháp định tính bao gồm quan sát lâm sàng, đánh giá triệu chứng và mô tả dịch tễ học. Phương pháp định lượng dựa trên PCR, ELISA, nuôi cấy vi sinh và phân tích trình tự gene.</p> <p>Các công cụ GIS và mô hình dự báo dịch bệnh sử dụng dữ liệu địa lý, khí hậu và thông tin di chuyển để dự báo xu hướng lây lan. Mô hình dịch tễ học toán học (SEIR) giúp ước tính tốc độ lây nhiễm và đánh giá tác động can thiệp:</p> <pre><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mfrac><mrow><mi>d</mi><mi>S</mi></mrow><mrow><mi>d</mi><mi>t</mi></mrow></mfrac><mo>=</mo><mo>−</mo><mi>β</mi><mi>S</mi><mi>I</mi><mo separator="true">,</mo><mspace width="1em"/><mfrac><mrow><mi>d</mi><mi>E</mi></mrow><mrow><mi>d</mi><mi>t</mi></mrow></mfrac><mo>=</mo><mi>β</mi><mi>S</mi><mi>I</mi><mo>−</mo><mi>σ</mi><mi>E</mi><mo separator="true">,</mo><mspace width="1em"/><mfrac><mrow><mi>d</mi><mi>I</mi></mrow><mrow><mi>d</mi><mi>t</mi></mrow></mfrac><mo>=</mo><mi>σ</mi><mi>E</mi><mo>−</mo><mi>γ</mi><mi>I</mi><mo separator="true">,</mo><mspace width="1em"/><mfrac><mrow><mi>d</mi><mi>R</mi></mrow><mrow><mi>d</mi><mi>t</mi></mrow></mfrac><mo>=</mo><mi>γ</mi><mi>I</mi></mrow><annotation encoding="application/x-tex">\frac{dS}{dt}=-\beta SI,\quad \frac{dE}{dt}=\beta SI-\sigma E,\quad \frac{dI}{dt}=\sigma E-\gamma I,\quad \frac{dR}{dt}=\gamma I</annotation></semantics></math></span></span></pre> <p>Trong đó <em>S</em>, <em>E</em>, <em>I</em>, <em>R</em> lần lượt là số người (sinh vật) nhạy cảm, tiềm ẩn, nhiễm và hồi phục; <em>β</em> tốc độ lây truyền, <em>σ</em> tốc độ tiến triển, <em>γ</em> tốc độ phục hồi.</p> <h2>Thách thức và Xu hướng Tương lai</h2> <p>Thách thức hiện nay gồm kháng kháng sinh, biến đổi khí hậu làm mở rộng vùng phân bố mầm bệnh, đô thị hóa tăng mật độ tiếp xúc và thương mại toàn cầu lan truyền nhanh chóng. Nhiệt độ và lượng mưa biến động tạo điều kiện thuận lợi cho vector và mầm bệnh phát triển.</p> <p>Xu hướng tương lai tập trung vào vaccine thế hệ mới sử dụng công nghệ mRNA, sử dụng CRISPR/Cas chỉnh sửa hệ miễn dịch hoặc giảm độc lực mầm bệnh. Phát triển nền tảng giám sát dựa trên IoT và AI để thu thập dữ liệu liên tục và đưa ra khuyến cáo kịp thời.</p> <p>Ứng dụng công nghệ omics (genomics, proteomics, metabolomics) giúp xác định dấu ấn sinh học (biomarkers) sớm của stress sinh học và nhiễm trùng, mở ra cơ hội phòng ngừa chủ động và quản lý sức khỏe sinh vật theo cá thể.</p> <h2>Tài liệu Tham khảo</h2> <ul> <li>World Health Organization. <em>One Health Approach</em>. Truy cập: https://www.who.int/initiatives/one-health</li> <li>Centers for Disease Control and Prevention. <em>Animal Health and Importation</em>. Truy cập: https://www.cdc.gov/animalimportation/animal_health.html</li> <li>World Health Organization. <em>Antimicrobial Resistance</em>. Truy cập: https://www.who.int/antimicrobial-resistance</li> <li>Smith J., et al. “Metrics for Evaluating Animal Health.” <em>Journal of Veterinary Science</em>, 2022.</li> <li>Jones D.S., et al. “One Health: Integrating Ecosystem and Human Health.” <em>Nature Reviews Microbiology</em>, 2021.</li> <li>Keeling M.J., Rohani P. <em>Modeling Infectious Diseases in Humans and Animals</em>. Princeton University Press, 2008.</li> </ul> </div></div><div class="el-divider el-divider--horizontal" style="--el-border-style:solid;" role="separator"><!--v-if--></div><h2>Các bài báo, nghiên cứu, công bố khoa học về chủ đề sức khỏe sinh vật:</h2><div><div><!--[--><div class="entity-item-container" data-v-d071913d><a href="/publication/Gut-Microbiota-in-Health-and-Disease/5d7f61f6-4529-4b47-a9fb-d8f6161590da" class="entity-title" data-v-d071913d><span data-v-d071913d>Vi sinh vật đường ruột trong sức khỏe và bệnh tật</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Physiological Reviews</span> - </span> Tập 90 Số 3 <span data-v-d071913d> - Trang 859-904</span><span data-v-d071913d> - 2010</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Vi sinh vật đường ruột là một tập hợp các vi sinh vật sinh sống trong toàn bộ đường tiêu hóa của động vật có vú. Thành phần của cộng đồng vi sinh vật này là đặc trưng cho từng chủ thể, tiến hóa trong suốt cuộc đời của một cá nhân và dễ bị tác động bởi cả những thay đổi bên ngoài và bên trong. Sự quan tâm gần đây đối với cấu trúc và chức năng của "cơ quan" này đã làm nổi bật vị trí trung tâ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #vi sinh vật đường ruột<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sức khỏe<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #bệnh tật<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #niêm mạc ruột<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #miễn dịch niêm mạc<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 3717<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://www.physiology.org/doi/10.1152/physrev.00045.2009" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Effects-of-Probiotics-Prebiotics-and-Synbiotics-on-Human-Health/bf8c1eb5-7a1c-4952-90e6-a1e8c8ba7663" class="entity-title" data-v-d071913d><span data-v-d071913d>Tác động của Probiotics, Prebiotics và Synbiotics đến Sức khỏe Con người</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Nutrients</span> - </span> Tập 9 Số 9 <span data-v-d071913d> - Trang 1021</span><!----></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Đường tiêu hóa của con người được định cư bởi một hệ sinh thái phức tạp của các vi sinh vật. Vi khuẩn đường ruột không chỉ là vi khuẩn hội sinh, mà chúng còn trải qua quá trình đồng tiến hóa cùng với vật chủ của chúng. Các vi khuẩn đường ruột có lợi có nhiều chức năng quan trọng, ví dụ, chúng sản xuất nhiều chất dinh dưỡng cho vật chủ, ngăn chặn các nhiễm trùng do các tác nhân gây bệnh đườ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #probiotics<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #prebiotics<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #synbiotics<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sức khỏe con người<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #vi sinh vật đường ruột<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 1706<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://www.mdpi.com/2072-6643/9/9/1021" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Gut-Microbiota-in-Health-Diverticular-Disease-Irritable-Bowel-Syndrome-and-Inflammatory-Bowel-Diseases-Time-for-Microbial-Marker-of-Gastrointestinal-Disorders/e1c5363d-da3f-44e9-aa45-ce550258aa9b" class="entity-title" data-v-d071913d><span data-v-d071913d>Vi sinh vật đường ruột trong sức khỏe, bệnh diverticular, hội chứng ruột kích thích và bệnh viêm ruột: Thời điểm cho dấu hiệu vi sinh vật của các rối loạn tiêu hóa</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Digestive Diseases</span> - </span> Tập 36 Số 1 <span data-v-d071913d> - Trang 56-65</span><span data-v-d071913d> - 2018</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Có rất ít dữ liệu về sự khác biệt trong thành phần vi sinh vật đường ruột giữa các bệnh đường tiêu hóa chính. Chúng tôi đã đánh giá sự khác biệt trong thành phần vi sinh vật đường ruột giữa bệnh diverticular không biến chứng (DD), hội chứng ruột kích thích (IBS) và bệnh viêm ruột (IBD). Bệnh nhân DD, IBS và IBD cùng với những người khỏe mạnh (CT) đã được tuyển chọn vào phòng khám ngoại trú...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 140<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://karger.com/DDI/article/doi/10.1159/000477205" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Le-microbiote-intestinal-composition-et-fonctions/ff8f5abe-06a3-44f1-8003-c5778f2457a0" class="entity-title" data-v-d071913d><span data-v-d071913d>Hệ vi sinh vật đường ruột: thành phần và chức năng</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Phytothérapie</span> - </span> <!----><span data-v-d071913d> - 2011</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Hệ vi sinh vật đường ruột, với mật độ đạt tối đa trong đại tràng (10^11 vi khuẩn trên mỗi gram), bao gồm hàng trăm loài. Mặc dù hồ sơ các loài này là đặc trưng cho mỗi cá nhân, ba nhánh (Firmicutes, Bacteroidetes, Actinobacteria) thường xuyên được phát hiện chiếm ưu thế ở người trưởng thành. Hệ vi sinh vật này nói chung ổn định theo thời gian ở người trưởng thành khỏe mạnh và trở lại trạng thái ba...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #vi sinh vật đường ruột<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #chức năng chuyển hóa<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hệ miễn dịch<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sức khỏe<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 12<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://link.springer.com/article/10.1007/s10298-011-0615-8" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Graduate-public-health-training-in-healthcare-of-refugee-asylum-seekers-and-clinical-human-rights-evaluation-of-an-innovative-curriculum/43472562-f6d2-43bc-92c0-829648011201" class="entity-title" data-v-d071913d><span data-v-d071913d>Đào tạo sau đại học về chăm sóc sức khỏe cho người tị nạn và quyền con người lâm sàng: đánh giá một chương trình giảng dạy đổi mới</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>International Journal of Public Health</span> - </span> Tập 61 <span data-v-d071913d> - Trang 279-287</span><span data-v-d071913d> - 2015</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Một chương trình giảng dạy đổi mới đã được phát triển để trang bị cho sinh viên sức khỏe cộng đồng những thái độ và kỹ năng phù hợp nhằm giải quyết vấn đề chăm sóc sức khỏe cho người xin tị nạn. Được triển khai vào năm 2005, chương trình giảng dạy bao gồm: (1) các buổi học lý thuyết bao gồm dịch tễ học và các di chứng sức khỏe của việc tra tấn, luật tị nạn và các phương pháp nhận diện nhu cầu chăm...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #chương trình giảng dạy đổi mới<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sức khỏe cộng đồng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #người tị nạn<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #chăm sóc sức khỏe<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #quyền con người<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #đào tạo sinh viên<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #đánh giá chương trình<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #năng lực văn hóa<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><!----><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://link.springer.com/article/10.1007/s00038-015-0754-z" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Assessment-of-general-condition-of-fish-inhabiting-a-moderately-contaminated-aquatic-environment/25cd9269-197e-4b6a-9b44-b4fc99a138b6" class="entity-title" data-v-d071913d><span data-v-d071913d>Đánh giá tình trạng chung của cá sống trong môi trường nước bị ô nhiễm vừa phải</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Springer Science and Business Media LLC</span> - </span> Tập 20 <span data-v-d071913d> - Trang 4954-4968</span><span data-v-d071913d> - 2013</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Việc đánh giá tình trạng chung của cá trong môi trường nước ô nhiễm vừa phải đã được thực hiện trên loài cá chub châu Âu (Squalius cephalus) được bắt vào tháng 9 năm 2009 tại sông Sutla ở Croatia. Mặc dù nồng độ ô nhiễm trong sông này (các yếu tố vi lượng và vĩ lượng, vi khuẩn), cũng như các thay đổi hóa lý (giảm độ bão hòa oxy, tăng độ dẫn điện), vẫn nằm trong giới hạn chấp nhận về môi trường, sự...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Ô nhiễm môi trường<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #cá chub châu Âu<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sinh học thủy sinh<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #chỉ số sức khỏe sinh vật<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #ô nhiễm vi sinh<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><!----><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="http://link.springer.com/10.1007/s11356-013-1463-x" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Depurated-fish-as-an-alternative-reference-for-field-based-biomarker-monitoring/0820fe3f-9d50-4b4e-9b4c-f89a3a923944" class="entity-title" data-v-d071913d><span data-v-d071913d>Cá được xử lý như một tham chiếu thay thế cho việc giám sát sinh trắc học tại hiện trường</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Springer Science and Business Media LLC</span> - </span> Tập 185 <span data-v-d071913d> - Trang 1331-1340</span><span data-v-d071913d> - 2012</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Toàn bộ khu vực cửa sông Swan-Canning, thuộc phía tây nam Australia, bị ảnh hưởng bởi hoạt động của con người, và việc chọn một địa điểm tham chiếu địa phương để đánh giá tác động của ô nhiễm môi trường đối với sức khỏe của sinh vật là không khả thi. Để xác định xem cá được xử lý trong điều kiện lab có thể được sử dụng như một sự thay thế cho một địa điểm tham chiếu hay không; cá bream đen trưởng ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Cá bream đen<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sinh trắc học<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #cửa sông<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sức khỏe sinh vật<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #ô nhiễm môi trường<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><!----><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://link.springer.com/article/10.1007/s10661-012-2635-8" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Elective-oocyte-cryopreservation-for-age-related-fertility-decline/7d3df92d-43a1-4116-a04d-d7c79f9a09fb" class="entity-title" data-v-d071913d><span data-v-d071913d>Lưu trữ trứng theo ý muốn cho sự suy giảm khả năng sinh sản liên quan đến độ tuổi</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Springer Science and Business Media LLC</span> - </span> Tập 38 <span data-v-d071913d> - Trang 1177-1186</span><span data-v-d071913d> - 2021</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Phụ nữ theo đuổi khả năng sinh sản ở độ tuổi cao ngày càng trở nên phổ biến. Kế hoạch hóa gia đình và giáo dục giới tính truyền thống thường tập trung vào việc ngừa thai và phòng ngừa các bệnh lây truyền qua đường tình dục. Hiện nay, cũng cần phải chú ý đến nhận thức về khả năng sinh sản và bảo tồn khả năng sinh sản. Bài viết này nhằm cập nhật những bằng chứng hiện có về lưu trữ trứng theo ý muốn,...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #lưu trữ trứng; khả năng sinh sản; giáo dục sức khỏe; tư vấn cá nhân hóa; hiệu quả chi phí; lão hóa sinh sản<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><!----><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://link.springer.com/article/10.1007/s10815-021-02072-w" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Extensive-colonization-with-carbapenemase-producing-microorganisms-in-Romanian-burn-patients-infectious-consequences-from-the-Colectiv-fire-disaster/0dc07cbd-82fb-44c3-a854-9acf39c10b1d" class="entity-title" data-v-d071913d><span data-v-d071913d>Sự thuộc địa hóa rộng rãi với các vi sinh vật sản xuất carbapenemase ở bệnh nhân bỏng Romania: Những hậu quả nhiễm trùng từ thảm họa hỏa hoạn Colectiv</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>European Journal of Clinical Microbiology and Infectious Diseases</span> - </span> Tập 37 <span data-v-d071913d> - Trang 175-183</span><span data-v-d071913d> - 2017</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Chăm sóc sức khỏe cho bệnh nhân bỏng nặng là rất chuyên biệt và có thể cần chuyển giao bệnh nhân quốc tế. Bệnh nhân bỏng có nguy cơ cao phát triển nhiễm trùng. Những bệnh nhân đã được nhập viện ở các quốc gia mà các vi sinh vật sản xuất carbapenemase (CPMO) đang lưu hành có thể phát triển những nhiễm trùng khó điều trị. Ngoài ra, có nguy cơ bùng phát CPMOs trong các trung tâm điều trị bỏng. Nghiên...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #bệnh nhân bỏng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #vi sinh vật sản xuất carbapenemase<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #chăm sóc sức khỏe<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #kiểm soát nhiễm trùng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #dịch tễ học<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><!----><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://link.springer.com/article/10.1007/s10096-017-3118-1" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Impact-of-tobramycin-on-the-performance-of-microbial-fuel-cell/ca67848b-f34c-46d2-a864-e0d101f048e9" class="entity-title" data-v-d071913d><span data-v-d071913d>Ảnh hưởng của tobramycin đối với hiệu suất của pin vi sinh vật</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Microbial Cell Factories</span> - </span> Tập 13 <span data-v-d071913d> - Trang 1-7</span><span data-v-d071913d> - 2014</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">Việc phát thải kháng sinh vào môi trường thủy sinh đã trở thành một vấn đề sức khỏe cộng đồng toàn cầu khi xử lý nước thải chứa kháng sinh. Khả năng của pin vi sinh vật (MFC) trong việc thu năng lượng từ chất thải hữu cơ và sinh khối tái tạo đang thu hút sự quan tâm ngày càng tăng trong việc xử lý nước thải. Trong bài báo này, chúng tôi đã điều tra phản ứng sinh điện hóa của một lớp biofilm hỗn hợ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tobramycin<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #pin vi sinh vật<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #biofilm điện hoạt<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #xử lý nước thải<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sức khỏe cộng đồng<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><!----><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-014-0091-6" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><!--]--></div><div class="el-row is-justify-end" style="" data-v-fa649ea5><!--[--><div class="pagination-container" data-v-fa649ea5><span data-v-fa649ea5> Tổng số: 31</span>    <div class="el-pagination is-background" data-v-fa649ea5><button type="button" class="btn-prev is-first" disabled aria-label="Go to previous page" aria-disabled="true"><i class="el-icon" style=""><!--[--><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1024 1024"><path fill="currentColor" d="M609.408 149.376 277.76 489.6a32 32 0 0 0 0 44.672l331.648 340.352a29.12 29.12 0 0 0 41.728 0 30.592 30.592 0 0 0 0-42.752L339.264 511.936l311.872-319.872a30.592 30.592 0 0 0 0-42.688 29.12 29.12 0 0 0-41.728 0z"></path></svg><!--]--></i></button><ul class="el-pager"><li class="is-active number" aria-current="true" aria-label="page 1" tabindex="0"> 1 </li><!--v-if--><!--[--><li class="number" aria-current="false" aria-label="page 2" tabindex="0">2</li><li class="number" aria-current="false" aria-label="page 3" tabindex="0">3</li><!--]--><!--v-if--><li class="number" aria-current="false" aria-label="page 4" tabindex="0">4</li></ul><button type="button" class="btn-next is-last" aria-label="Go to next page" aria-disabled="false"><i class="el-icon" style=""><!--[--><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1024 1024"><path fill="currentColor" d="M340.864 149.312a30.592 30.592 0 0 0 0 42.752L652.736 512 340.864 831.872a30.592 30.592 0 0 0 0 42.752 29.12 29.12 0 0 0 41.728 0L714.24 534.336a32 32 0 0 0 0-44.672L382.592 149.376a29.12 29.12 0 0 0-41.728 0z"></path></svg><!--]--></i></button></div></div><!--]--></div><div></div></div><!--]--></div><div class="el-col el-col-24 el-col-xs-24 el-col-sm-24 el-col-md-7 is-guttered" style="padding-right:10px;padding-left:10px;"><!--[--><h2 class="underline-title">Chủ đề khác</h2><div class="post-page-container"><!--[--><div class="entity-item-container"><a href="/topic/nghiên cứu ngẫu nhiên" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#nghiên cứu ngẫu nhiên<!--]--></span><!--v-if--></span><br><p>Nghiên cứu ngẫu nhiên là gì? Các công bố khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/pt score" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#pt score<!--]--></span><!--v-if--></span><br><p>PT Score à gì? Các nghiên cứu khoa học về PT Score</p></a></div><div class="entity-item-container"><a href="/topic/tĩnh mạch thận" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#tĩnh mạch thận<!--]--></span><!--v-if--></span><br><p>Tĩnh mạch thận là gì? Các công bố khoa học về Tĩnh mạch thận</p></a></div><div class="entity-item-container"><a href="/topic/bức xạ electron" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#bức xạ electron<!--]--></span><!--v-if--></span><br><p>Bức xạ electron là gì? Các bài nghiên cứu khoa học</p></a></div><div class="entity-item-container"><a href="/topic/diệp lục" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#diệp lục<!--]--></span><!--v-if--></span><br><p>Diệp lục là gì? Các bài báo nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/tiếng hoa" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#tiếng hoa<!--]--></span><!--v-if--></span><br><p>Tiếng hoa là gì? Các công bố khoa học về Tiếng hoa</p></a></div><div class="entity-item-container"><a href="/topic/phương pháp đo lường" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#phương pháp đo lường<!--]--></span><!--v-if--></span><br><p>Phương pháp đo lường là gì? Các bài báo nghiên cứu khoa học</p></a></div><div class="entity-item-container"><a href="/topic/phẫu thuật bắc cầu chủ vành" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#phẫu thuật bắc cầu chủ vành<!--]--></span><!--v-if--></span><br><p>Phẫu thuật bắc cầu chủ vành là gì? Các công bố khoa học</p></a></div><div class="entity-item-container"><a href="/topic/cây cà chua" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#cây cà chua<!--]--></span><!--v-if--></span><br><p>Cây cà chua là gì? Các bài nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/huyết áp" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#huyết áp<!--]--></span><!--v-if--></span><br><p>Huyết áp là gì? 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Công cụ trợ giúp người nghiên cứu, tạp chí, đơn vị nghiên cứu tra cứu, phân tích và thống kê dữ liệu nghiên cứu khoa học tại Việt Nam và quốc tế. <br data-v-3f34e5e0> ScholarHub KHÔNG đăng thông tin tổng hợp, KHÔNG đăng lại nội dung từ các trang báo chí Việt Nam hoặc trang thông tin điện tử khác tại Việt Nam. </p><div class="el-row" style="" data-v-3f34e5e0><!--[--><div class="el-col el-col-24 el-col-xs-24 el-col-sm-24 el-col-md-12 el-col-lg-12 link-container" style="" data-v-3f34e5e0><!--[--><h4 data-v-3f34e5e0>Thông tin, cập nhật</h4><p data-v-3f34e5e0><a href="https://docs.google.com/forms/d/e/1FAIpQLScPJI8r9B2cFAOO-00E0cAsU1cVnZ1_pk3YaXn5c21vgNrdfQ/viewform?usp=sf_link" target="_blank" data-v-3f34e5e0> Đăng ký Tạp chí tham gia vào Scholar Hub </a></p><p data-v-3f34e5e0><a href="https://forms.gle/bWrbmfR549VNF1UP7" target="_blank" data-v-3f34e5e0>Phản hồi ý kiến về Scholar Hub</a></p><p data-v-3f34e5e0><a href="/post/browse" class="" data-v-3f34e5e0>Bài viết, nội dung cập nhật</a></p><p data-v-3f34e5e0><a href="/topic/browse" class="" data-v-3f34e5e0>Chủ đề khoa học</a></p><!--]--></div><div class="el-col el-col-24 el-col-xs-24 el-col-sm-24 el-col-md-12 el-col-lg-12" style="" data-v-3f34e5e0><!--[--><h4 data-v-3f34e5e0>Website liên kết</h4><p data-v-3f34e5e0><a href="https://scibase.metis.vn" target="_blank" rel="nofollow" data-v-3f34e5e0>Hệ thống CSDL Khoa học &amp; Công nghệ</a></p><p data-v-3f34e5e0><a href="https://kiemtratailieu.vn" target="_blank" rel="nofollow" data-v-3f34e5e0>Phần mềm kiểm tra trùng lặp Kiểm Tra Tài Liệu</a></p><p data-v-3f34e5e0><a href="https://vojs.vn" target="_blank" rel="nofollow" data-v-3f34e5e0>Phần mềm xuất bản tạp chí điện tử VOJS</a></p><p data-v-3f34e5e0><a href="https://letqa.vn" target="_blank" rel="nofollow" data-v-3f34e5e0>Nền tảng trắc nghiệm và đề thi đa lĩnh vực LetQA</a></p><!--]--></div><!--]--></div><!--]--></div><!--]--></div><br data-v-3f34e5e0><div class="flex-center" data-v-3f34e5e0><p data-v-3f34e5e0>Copyright © 2023 ScholarHub - Scholar Hub. 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khỏe sinh vật","Sức khỏe sinh vật là gì? Các nghiên cứu khoa học liên quan","Sức khỏe sinh vật là trạng thái cân bằng nội tại và khả năng sinh trưởng, sinh sản, thích nghi và đề kháng stress sinh học của cá thể hoặc quần thể. Khái niệm này bao gồm chức năng sinh lý, miễn dịch và hành vi, phản ánh mối tương tác với môi trường, quan trọng cho an ninh lương thực, đa dạng sinh học. ","\u003Cdiv>\u003Ch2>Định nghĩa Sức khỏe Sinh vật\u003C/h2>\n\u003Cp>Sức khỏe sinh vật (biological health) là trạng thái cân bằng nội tại và khả năng thích nghi, sinh trưởng, sinh sản của một cá thể hoặc quần thể sinh vật trong hệ sinh thái của nó. Khái niệm này không chỉ bao gồm các chức năng sinh lý cơ bản như trao đổi chất, sinh sản và phát triển, mà còn cả khả năng chống chịu với stress sinh học (nhiệt độ, nhiễm khuẩn) và phục hồi sau tổn thương.\u003C/p>\n\u003Cp>Ở cấp độ cá thể, sức khỏe sinh vật thể hiện qua các chỉ tiêu như tỷ lệ sống, tốc độ tăng trưởng, khả năng sinh sản và năng lực phòng vệ miễn dịch. Ở cấp độ quần thể, cần đánh giá thêm các yếu tố như mật độ, cấu trúc tuổi và khả năng duy trì quần sự đa dạng di truyền. Việc duy trì sức khỏe sinh vật là yếu tố quyết định cho sự ổn định và bền vững của hệ sinh thái.\u003C/p>\n\u003Cp>Khả năng duy trì năng suất sinh học và chu trình sinh địa hóa phụ thuộc trực tiếp vào sức khỏe của các loài chủ chốt (keystone species) và quần xã vi sinh vật đất – nước. Khi một hoặc nhiều loài quan trọng bị suy giảm sức khỏe, Trung tâm Điều phối Một Sức khỏe (One Health) nhấn mạnh hệ quả lan rộng đến sức khỏe con người và vật nuôi (\u003Ca href=\"https://www.who.int/initiatives/one-health\" target=\"_blank\">WHO One Health\u003C/a>).\u003C/p>\n\n\u003Ch2>Phạm vi và Tầm quan trọng\u003C/h2>\n\u003Cp>Phạm vi của sức khỏe sinh vật bao gồm từ cấp độ phân tử (sinh hóa, di truyền) đến cấp độ sinh thái (mối tương tác giữa sinh vật và môi trường). Mỗi cấp độ có những chỉ số và tiêu chuẩn đánh giá riêng, tuy nhiên mục tiêu chung là đảm bảo chức năng sinh trưởng, sinh sản và duy trì quần thể qua các điều kiện biến động.\u003C/p>\n\u003Cp>Vai trò của sức khỏe sinh vật đặc biệt nổi bật trong lĩnh vực nông nghiệp, chăn nuôi và nuôi trồng thủy sản, nơi năng suất sản phẩm gắn liền với khả năng kháng bệnh và tăng trưởng tối ưu của vật nuôi hoặc cây trồng. Đồng thời, trong bảo tồn đa dạng sinh học, sức khỏe sinh vật giúp dự báo nguy cơ tuyệt chủng và đề xuất biện pháp phục hồi quần xã.\u003C/p>\n\u003Cul>\n \u003Cli>An ninh lương thực: đảm bảo nguồn cung thực phẩm ổn định, giảm thiểu thất thoát do dịch bệnh;\u003C/li>\n \u003Cli>Sức khỏe cộng đồng: ngăn ngừa bệnh truyền zoonotic (qua động vật sang người);\u003C/li>\n \u003Cli>Bảo tồn hệ sinh thái: giảm thiểu mất cân bằng chu trình dinh dưỡng và giảm ô nhiễm môi trường.\u003C/li>\n\u003C/ul>\n\u003Cp>Liên minh Nông Lương Liên Hiệp Quốc (FAO) coi định hướng nâng cao sức khỏe sinh vật là chìa khóa cho phát triển nông nghiệp bền vững và thích ứng với biến đổi khí hậu (\u003Ca href=\"https://www.fao.org/biological-control/en/\" target=\"_blank\">FAO Biological Control\u003C/a>).\u003C/p>\n\n\u003Ch2>Các Yếu tố Ảnh hưởng\u003C/h2>\n\u003Cp>Yếu tố sinh học: mầm bệnh (virus, vi khuẩn, ký sinh trùng), vi sinh vật cộng sinh và các loài đối kháng. Sự cân bằng giữa hệ vi sinh vật có lợi và có hại quyết định phần lớn khả năng đề kháng và phục hồi của sinh vật chủ.\u003C/p>\n\u003Cp>Yếu tố môi trường: bao gồm điều kiện nhiệt độ, độ ẩm, pH, độ oxy hoà tan trong nước và mức độ ô nhiễm hoá chất (kim loại nặng, thuốc trừ sâu). Ví dụ, nhiệt độ nước nuôi trồng thủy sản từ 25–30 °C thường tối ưu cho ấu trùng phát triển, trong khi ô nhiễm hữu cơ cao làm giảm độ oxy và gia tăng stress sinh học.\u003C/p>\n\u003Cp>Yếu tố di truyền và dinh dưỡng: tính thích nghi di truyền quyết định khả năng chịu hạn, chịu nóng hoặc kháng bệnh; dinh dưỡng đầy đủ (đạm, khoáng chất, vitamin) đảm bảo hệ miễn dịch hoạt động hiệu quả. Sự tương tác giữa genotype và môi trường (G×E) là chìa khóa để chọn giống và tối ưu hóa chế độ nuôi dưỡng.\u003C/p>\n\n\u003Ch2>Chỉ số và Đơn vị Đo lường\u003C/h2>\n\u003Cp>Các chỉ số thường dùng để đánh giá sức khỏe sinh vật bao gồm:\u003C/p>\n\u003Cul>\n \u003Cli>Tỷ lệ sống (Survival Rate, SR): tỷ lệ phần trăm cá thể còn sống sau một khoảng thời gian xác định;\u003C/li>\n \u003Cli>Tốc độ tăng trưởng khối lượng trung bình hàng ngày (Average Daily Gain, ADG): đo hiệu quả dinh dưỡng và năng suất sinh khối;\u003C/li>\n \u003Cli>Chỉ số kháng bệnh (Disease Resistance Index, DRI): phản ánh khả năng sinh vật chủ chống chịu với mầm bệnh.\u003C/li>\n\u003C/ul>\n\u003Cpre>\u003Cscript type=\"math/tex\">DRI = \\frac{1}{n}\\sum_{i=1}^n \\frac{S_i - C_i}{C_i}\u003C/script>\u003C/pre>\n\u003Cp>Trong đó \u003Cem>S\u003Csub>i\u003C/sub>\u003C/em> là tỷ lệ sống ở nhóm thử nghiệm, \u003Cem>C\u003Csub>i\u003C/sub>\u003C/em> là tỷ lệ sống ở nhóm đối chứng, và \u003Cem>n\u003C/em> là số đợt thử nghiệm. Giá trị DRI càng cao chứng tỏ mức độ kháng bệnh càng mạnh.\u003C/p>\n\u003Ctable>\n \u003Cthead>\n \u003Ctr>\n \u003Cth>Chỉ số\u003C/th>\n \u003Cth>Công thức/Tính toán\u003C/th>\n \u003Cth>Ứng dụng\u003C/th>\n \u003C/tr>\n \u003C/thead>\n \u003Ctbody>\n \u003Ctr>\n \u003Ctd>SR\u003C/td>\n \u003Ctd>\u003Cscript type=\"math/tex\">SR = \\frac{N_{alive}}{N_{total}} \\times 100\\%\u003C/script>\u003C/td>\n \u003Ctd>Đánh giá khả năng sống sót\u003C/td>\n \u003C/tr>\n \u003Ctr>\n \u003Ctd>ADG\u003C/td>\n \u003Ctd>\u003Cscript type=\"math/tex\">ADG = \\frac{W_{final} - W_{initial}}{T}\\end{script>\u003C/td>\n \u003Ctd>Đo hiệu suất tăng trưởng\u003C/td>\n \u003C/tr>\n \u003Ctr>\n \u003Ctd>DRI\u003C/td>\n \u003Ctd>\u003Cscript type=\"math/tex\">1/n \\sum (S_i-C_i)/C_i\u003C/script>\u003C/td>\n \u003Ctd>Đánh giá kháng bệnh\u003C/td>\n \u003C/tr>\n \u003C/tbody>\n\u003C/table>\n\u003Cp>Việc sử dụng đồng bộ nhiều chỉ số giúp cung cấp cái nhìn toàn diện về sức khỏe sinh vật, từ đó đề xuất biện pháp cải thiện và quản lý bền vững.\u003C/p>\n\u003Ch2>Tương tác Vật chủ – Mầm bệnh\u003C/h2>\n\u003Cp>Quá trình tương tác giữa sinh vật chủ và mầm bệnh quyết định kết quả cuối cùng của nhiễm trùng, bao gồm xâm nhập, nhân lên và lan truyền. Mầm bệnh có thể là virus, vi khuẩn, ký sinh trùng hoặc nấm, mỗi loại sở hữu cơ chế xâm lấn và độc lực khác nhau. Ví dụ, vi khuẩn gây bệnh đường ruột tiết độc tố làm băng hoại biểu mô, trong khi virus xâm nhập tế bào rồi sử dụng bộ máy di truyền của chủ để sinh sản.\u003C/p>\n\u003Cp>Độc lực của mầm bệnh (virulence) được định lượng qua chỉ số LD\u003Csub>50\u003C/sub> (liều gây chết 50% quần thể thí nghiệm) hoặc ID\u003Csub>50\u003C/sub> (liều lây nhiễm cho 50%). Mức độ độc lực càng cao thì khả năng gây tổn thương và tỷ lệ tử vong của vật chủ càng lớn. Đồng thời, khả năng né tránh hệ miễn dịch của mầm bệnh—ví dụ như lớp vỏ polysaccharide của một số vi khuẩn—giúp tăng cường khả năng tồn tại và truyền bệnh.\u003C/p>\n\u003Cp>Cân bằng mối quan hệ “vũ khí và lá chắn” giữa mầm bệnh và vật chủ quyết định diễn biến bệnh: nếu hệ miễn dịch mạnh, mầm bệnh sẽ bị kiểm soát; ngược lại, mầm bệnh vượt qua hàng rào bảo vệ sẽ gây bệnh nghiêm trọng. Nghiên cứu mô hình in vitro (nuôi cấy tế bào) và in vivo (động vật thí nghiệm) là công cụ quan trọng để đánh giá cơ chế tương tác và tìm kiếm kháng sinh, kháng thể trung hòa hiệu quả (\u003Ca href=\"https://www.cdc.gov/animalimportation/animal_health.html\" target=\"_blank\">CDC Animal Health\u003C/a>).\u003C/p>\n\n\u003Ch2>Hệ miễn dịch và Đề kháng\u003C/h2>\n\u003Cp>Hệ miễn dịch vật chủ bao gồm miễn dịch bẩm sinh và miễn dịch thu được, phối hợp chặt chẽ để phát hiện và tiêu diệt mầm bệnh. Miễn dịch bẩm sinh khởi phát nhanh chóng nhờ đại thực bào, tế bào đuôi gai và protein bổ thể; cơ chế này không đặc hiệu nhưng tạo hàng rào bảo vệ ban đầu.\u003C/p>\n\u003Cp>Miễn dịch thu được phát triển chậm hơn nhưng có tính đặc hiệu cao, dựa trên tế bào B sản xuất kháng thể và tế bào T tiêu diệt. Kháng thể gắn kết kháng nguyên trên bề mặt mầm bệnh, kích hoạt bổ thể hoặc trung hòa trực tiếp. Tế bào T CD8+ nhận diện và tiêu diệt tế bào bị nhiễm, trong khi tế bào T CD4+ hỗ trợ quá trình sinh kháng thể và điều hòa phản ứng viêm.\u003C/p>\n\u003Col>\n \u003Cli>\u003Cstrong>Miễn dịch bẩm sinh:\u003C/strong> thông qua hàng rào vật lý (da, niêm mạc), thực bào và bổ thể.\u003C/li>\n \u003Cli>\u003Cstrong>Miễn dịch thu được:\u003C/strong> tế bào lympho T và B, kháng thể IgG, IgM, IgA.\u003C/li>\n \u003Cli>\u003Cstrong>Cơ chế điều hòa:\u003C/strong> cytokine, chemokine giám sát độ mạnh và thời gian của phản ứng viêm.\u003C/li>\n\u003C/ol>\n\u003Cp>Kháng kháng sinh và kháng kháng virus ngày càng gia tăng do chọn lọc từ lạm dụng thuốc. Giải pháp gồm phát triển kháng sinh mới, sử dụng phage therapy và điều chỉnh chế độ điều trị để giảm áp lực chọn lọc lên vi khuẩn (\u003Ca href=\"https://www.who.int/antimicrobial-resistance\" target=\"_blank\">WHO AMR\u003C/a>).\u003C/p>\n\n\u003Ch2>Tích hợp với Sức khỏe Hệ sinh thái\u003C/h2>\n\u003Cp>Mô hình One Health kết nối sức khỏe sinh vật, con người và môi trường, nhấn mạnh tính liên ngành và toàn diện. Khi một thành phần trong chuỗi – bao gồm động vật hoang dã, vật nuôi, vi sinh vật môi trường – bị ảnh hưởng, hệ sinh thái tổng thể trở nên mất cân bằng và tăng nguy cơ bùng phát dịch bệnh.\u003C/p>\n\u003Cp>Ví dụ, phá rừng làm thay đổi quần xã động vật, thúc đẩy sự tiếp xúc gần hơn giữa virus dơi và người, dẫn đến các ổ dịch mới. Đồng thời, ô nhiễm nước và đất ảnh hưởng đến quần xã vi sinh vật, làm giảm khả năng phân giải chất hữu cơ và gia tăng các mầm bệnh dạng ký sinh.\u003C/p>\n\u003Ctable>\n \u003Cthead>\n \u003Ctr>\n \u003Cth>Thành phần\u003C/th>\n \u003Cth>Ảnh hưởng\u003C/th>\n \u003Cth>Giải pháp tích hợp\u003C/th>\n \u003C/tr>\n \u003C/thead>\n \u003Ctbody>\n \u003Ctr>\n \u003Ctd>Động vật hoang dã\u003C/td>\n \u003Ctd>Ổ chứa mầm bệnh\u003C/td>\n \u003Ctd>Giám sát động vật, hạn chế tiếp xúc\u003C/td>\n \u003C/tr>\n \u003Ctr>\n \u003Ctd>Vật nuôi\u003C/td>\n \u003Ctd>Lây chéo zoonotic\u003C/td>\n \u003Ctd>Tiêm phòng, quản lý chất thải\u003C/td>\n \u003C/tr>\n \u003Ctr>\n \u003Ctd>Vi sinh vật môi trường\u003C/td>\n \u003Ctd>Cân bằng vi sinh vật bị phá vỡ\u003C/td>\n \u003Ctd>Quản lý ô nhiễm, phục hồi hệ vi sinh vật\u003C/td>\n \u003C/tr>\n \u003C/tbody>\n\u003C/table>\n\u003Cp>Tích hợp One Health đòi hỏi hợp tác giữa bác sĩ thú y, nhà dịch tễ học, môi trường học và chính sách công để xây dựng chương trình giám sát đa tầng và can thiệp kịp thời.\u003C/p>\n\n\u003Ch2>Phương pháp Giám sát và Đánh giá\u003C/h2>\n\u003Cp>Giám sát sức khỏe sinh vật dùng kết hợp phương pháp định tính và định lượng. Phương pháp định tính bao gồm quan sát lâm sàng, đánh giá triệu chứng và mô tả dịch tễ học. Phương pháp định lượng dựa trên PCR, ELISA, nuôi cấy vi sinh và phân tích trình tự gene.\u003C/p>\n\u003Cp>Các công cụ GIS và mô hình dự báo dịch bệnh sử dụng dữ liệu địa lý, khí hậu và thông tin di chuyển để dự báo xu hướng lây lan. Mô hình dịch tễ học toán học (SEIR) giúp ước tính tốc độ lây nhiễm và đánh giá tác động can thiệp:\u003C/p>\n\u003Cpre>\u003Cscript type=\"math/tex\">\\frac{dS}{dt}=-\\beta SI,\\quad \\frac{dE}{dt}=\\beta SI-\\sigma E,\\quad \\frac{dI}{dt}=\\sigma E-\\gamma I,\\quad \\frac{dR}{dt}=\\gamma I\u003C/script>\u003C/pre>\n\u003Cp>Trong đó \u003Cem>S\u003C/em>, \u003Cem>E\u003C/em>, \u003Cem>I\u003C/em>, \u003Cem>R\u003C/em> lần lượt là số người (sinh vật) nhạy cảm, tiềm ẩn, nhiễm và hồi phục; \u003Cem>β\u003C/em> tốc độ lây truyền, \u003Cem>σ\u003C/em> tốc độ tiến triển, \u003Cem>γ\u003C/em> tốc độ phục hồi.\u003C/p>\n\n\u003Ch2>Thách thức và Xu hướng Tương lai\u003C/h2>\n\u003Cp>Thách thức hiện nay gồm kháng kháng sinh, biến đổi khí hậu làm mở rộng vùng phân bố mầm bệnh, đô thị hóa tăng mật độ tiếp xúc và thương mại toàn cầu lan truyền nhanh chóng. Nhiệt độ và lượng mưa biến động tạo điều kiện thuận lợi cho vector và mầm bệnh phát triển.\u003C/p>\n\u003Cp>Xu hướng tương lai tập trung vào vaccine thế hệ mới sử dụng công nghệ mRNA, sử dụng CRISPR/Cas chỉnh sửa hệ miễn dịch hoặc giảm độc lực mầm bệnh. Phát triển nền tảng giám sát dựa trên IoT và AI để thu thập dữ liệu liên tục và đưa ra khuyến cáo kịp thời.\u003C/p>\n\u003Cp>Ứng dụng công nghệ omics (genomics, proteomics, metabolomics) giúp xác định dấu ấn sinh học (biomarkers) sớm của stress sinh học và nhiễm trùng, mở ra cơ hội phòng ngừa chủ động và quản lý sức khỏe sinh vật theo cá thể.\u003C/p>\n\n\u003Ch2>Tài liệu Tham khảo\u003C/h2>\n\u003Cul>\n \u003Cli>World Health Organization. \u003Cem>One Health Approach\u003C/em>. Truy cập: https://www.who.int/initiatives/one-health\u003C/li>\n \u003Cli>Centers for Disease Control and Prevention. \u003Cem>Animal Health and Importation\u003C/em>. Truy cập: https://www.cdc.gov/animalimportation/animal_health.html\u003C/li>\n \u003Cli>World Health Organization. \u003Cem>Antimicrobial Resistance\u003C/em>. Truy cập: https://www.who.int/antimicrobial-resistance\u003C/li>\n \u003Cli>Smith J., et al. “Metrics for Evaluating Animal Health.” \u003Cem>Journal of Veterinary Science\u003C/em>, 2022.\u003C/li>\n \u003Cli>Jones D.S., et al. “One Health: Integrating Ecosystem and Human Health.” \u003Cem>Nature Reviews Microbiology\u003C/em>, 2021.\u003C/li>\n \u003Cli>Keeling M.J., Rohani P. \u003Cem>Modeling Infectious Diseases in Humans and Animals\u003C/em>. Princeton University Press, 2008.\u003C/li>\n\u003C/ul>\n\u003C/div>",{"id":314,"researcherId":22,"name":315,"imageUrl":316},2633,"Hoài Đặng","https://lh3.googleusercontent.com/a/ACg8ocLVXVafUxrnnC_H60UeQdpLE3UgeKGCSesypz_6Vi59B-n9C41A=s96-c",{"id":314,"researcherId":22,"name":315,"imageUrl":316},[309],"PUBLISHED","2025-08-05T09:17:12.570+00:00","2025-09-08T11:34:58.669+00:00","2025-08-05T09:46:58.895+00:00",74,[325,328,331,334,337,340,343,346,349,352],{"id":326,"title":327},"nghiên cứu ngẫu nhiên","Nghiên cứu ngẫu nhiên là gì? Các công bố khoa học liên quan",{"id":329,"title":330},"pt score","PT Score à gì? Các nghiên cứu khoa học về PT Score",{"id":332,"title":333},"tĩnh mạch thận","Tĩnh mạch thận là gì? Các công bố khoa học về Tĩnh mạch thận",{"id":335,"title":336},"bức xạ electron","Bức xạ electron là gì? Các bài nghiên cứu khoa học",{"id":338,"title":339},"diệp lục","Diệp lục là gì? Các bài báo nghiên cứu khoa học liên quan",{"id":341,"title":342},"tiếng hoa","Tiếng hoa là gì? Các công bố khoa học về Tiếng hoa",{"id":344,"title":345},"phương pháp đo lường","Phương pháp đo lường là gì? Các bài báo nghiên cứu khoa học",{"id":347,"title":348},"phẫu thuật bắc cầu chủ vành","Phẫu thuật bắc cầu chủ vành là gì? Các công bố khoa học",{"id":350,"title":351},"cây cà chua","Cây cà chua là gì? Các bài nghiên cứu khoa học liên quan",{"id":353,"title":354},"huyết áp","Huyết áp là gì? Các công bố khoa học về Huyết áp",{"meta":356,"data":358},{"total":357},"31",[359,1623,2544,2953,3077,3230,3527,3721,3959,4184],{"id":360,"createTime":361,"updateTime":362,"relativeEntities":363,"slug":364,"properties":365,"entityType":242,"verifyStatus":382,"verifyTime":361,"verifyNote":383,"syncStatus":384,"languages":385,"translateLanguages":387,"viewCount":23,"primaryUrl":389,"fullTextUrl":22,"authors":390,"publicationType":244,"publisherRelationship":463,"citationCount":532,"citationInfo":533,"publishDate":548,"publishYear":549,"citationAnalyzeStatus":384,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":550,"isForceReanalyzing":19},"5d7f61f6-4529-4b47-a9fb-d8f6161590da","2024-10-13T00:06:00.575+00:00","2025-02-08T00:10:09.665+00:00",[],"Gut-Microbiota-in-Health-and-Disease",{"mag":366,"keywords":368,"openalex":370,"abstract":372,"title":375,"pm":378,"doi":380},{"VOID":367},"2110235509",{"VI":369},"vi sinh vật đường ruột, sức khỏe, bệnh tật, niêm mạc ruột, miễn dịch niêm mạc",{"VOID":371},"W2110235509",{"EN":373,"VI":374},"\u003Cjats:p>Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this “organ” has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host physiology, from nutritional status to behavior and stress response. Additionally, they can be a central or a contributing cause of many diseases, affecting both near and far organ systems. The overall balance in the composition of the gut microbial community, as well as the presence or absence of key species capable of effecting specific responses, is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond. The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined, but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells. The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.\u003C/jats:p>","\u003Cjats:p>Vi sinh vật đường ruột là một tập hợp các vi sinh vật sinh sống trong toàn bộ đường tiêu hóa của động vật có vú. Thành phần của cộng đồng vi sinh vật này là đặc trưng cho từng chủ thể, tiến hóa trong suốt cuộc đời của một cá nhân và dễ bị tác động bởi cả những thay đổi bên ngoài và bên trong. Sự quan tâm gần đây đối với cấu trúc và chức năng của \"cơ quan\" này đã làm nổi bật vị trí trung tâm của nó trong sức khỏe và bệnh tật. Vi sinh vật đường ruột có vai trò mật thiết trong nhiều khía cạnh của sinh lý bình thường của chủ thể, từ trạng thái dinh dưỡng đến hành vi và phản ứng với stress. Ngoài ra, chúng có thể là nguyên nhân chính hoặc nguyên nhân góp phần vào nhiều bệnh, ảnh hưởng đến cả các hệ thống cơ quan gần và xa. Sự cân bằng tổng thể trong thành phần của cộng đồng vi sinh vật đường ruột, cũng như sự hiện diện hoặc vắng mặt của các loài vi sinh vật chính có khả năng gây ra các phản ứng cụ thể, là rất quan trọng trong việc đảm bảo trạng thái cân bằng hoặc sự thiếu hụt tại niêm mạc ruột và các khu vực khác. Cơ chế mà vi sinh vật thực hiện lợi ích hoặc ảnh hưởng có hại của chúng vẫn chủ yếu chưa được xác định rõ, nhưng bao gồm cả việc giải phóng các phân tử tín hiệu và việc nhận diện các epitop vi khuẩn bởi cả tế bào biểu mô ruột và tế bào miễn dịch niêm mạc. Những tiến bộ trong việc mô hình hóa và phân tích vi sinh vật đường ruột sẽ nâng cao hiểu biết của chúng ta về vai trò của chúng trong sức khỏe và bệnh tật, cho phép tùy chỉnh các liệu pháp và biện pháp phòng ngừa hiện tại và trong tương lai.\u003C/jats:p>",{"EN":376,"VI":377},"Gut Microbiota in Health and Disease","Vi sinh vật đường ruột trong sức khỏe và bệnh tật",{"VOID":379},"20664075",{"VOID":381},"10.1152/physrev.00045.2009","VERIFIED","Auto Verify","PENDING",[386],"EN",[388],"VI","https://www.physiology.org/doi/10.1152/physrev.00045.2009",[391,412,429,446],{"id":392,"sortIndex":157,"researcher":22,"roles":393,"affiliations":394,"properties":405},"dee3dfdc-6b3e-4247-95b2-aeededb9199b",[],[395],{"id":396,"sortIndex":23,"affiliation":397,"properties":22},"c1978840-89a1-47f9-9d17-737a0fe7e2b6",{"id":398,"createTime":399,"updateTime":399,"relativeEntities":400,"slug":401,"properties":402,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"2c4c2551-5acf-41c5-bcc7-ebdf9378b324","2024-10-13T00:06:00.593+00:00",[],"Michael-Smith-Laboratories-Department-of-Microbiology-and-Immunology-and-Department-of-Biochemistry-and-Molecular-Biology-The-University-of-British-Columbia-Vancouver-British-Columbia-Canada",{"title":403},{"EN":404},"Michael Smith Laboratories, Department of Microbiology and Immunology, and Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada",{"openalex":406,"orcid":408,"title":410},{"VOID":407},"A5029589860",{"VOID":409},"https://orcid.org/0000-0003-1686-0788",{"EN":411},"L. Caetano M. Antunes",{"id":413,"sortIndex":148,"researcher":22,"roles":414,"affiliations":415,"properties":422},"15750776-7239-4fee-9f8c-718e11cd6b18",[],[416],{"id":417,"sortIndex":23,"affiliation":418,"properties":22},"b3bc6b55-fea3-49bd-be09-40cb25165f2f",{"id":398,"createTime":399,"updateTime":399,"relativeEntities":419,"slug":401,"properties":420,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":421},{"EN":404},{"openalex":423,"orcid":425,"title":427},{"VOID":424},"A5072527169",{"VOID":426},"https://orcid.org/0000-0002-2785-7114",{"EN":428},"Sarah Russell",{"id":430,"sortIndex":167,"researcher":22,"roles":431,"affiliations":432,"properties":439},"7818c4a2-7a8c-40a9-95e4-3375e38877a4",[],[433],{"id":434,"sortIndex":23,"affiliation":435,"properties":22},"bb7830a7-356d-4ec5-9cdb-2f4e7f3d849c",{"id":398,"createTime":399,"updateTime":399,"relativeEntities":436,"slug":401,"properties":437,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":438},{"EN":404},{"openalex":440,"orcid":442,"title":444},{"VOID":441},"A5030919684",{"VOID":443},"https://orcid.org/0000-0001-5303-6128",{"EN":445},"B. Brett Finlay",{"id":447,"sortIndex":23,"researcher":22,"roles":448,"affiliations":449,"properties":456},"5995f962-4806-44e5-8837-130aeb1b84bc",[],[450],{"id":451,"sortIndex":23,"affiliation":452,"properties":22},"9a045404-fc06-4c3e-83e5-6fd69095ac18",{"id":398,"createTime":399,"updateTime":399,"relativeEntities":453,"slug":401,"properties":454,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":455},{"EN":404},{"openalex":457,"orcid":459,"title":461},{"VOID":458},"A5086578132",{"VOID":460},"https://orcid.org/0000-0001-5042-7932",{"EN":462},"Inna Sekirov",{"url":22,"publisher":464,"properties":525},{"id":465,"createTime":466,"updateTime":467,"relativeEntities":468,"slug":469,"properties":470,"entityType":136,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":481,"manageAffiliations":482,"indexDatabases":483,"url":524,"thumbnailPath":22,"statistic":22,"gsStatistic":22,"type":22,"analyzePriority":22},"db85de8c-fd8e-4d9c-a76f-a69063401f48","2023-05-29T10:24:14.163+00:00","2025-02-10T17:38:53.553+00:00",[],"Physiological-Reviews",{"country":471,"issn":473,"introduce":475,"eissn":477,"title":479},{"VOID":472},"US",{"VOID":474},"15221210",{"EN":476},"e American Physiological Society (APS) is a nonprofit devoted to fostering education, scientific research, and dissemination of information in the physiological sciences. The Society was founded in 1887 with 28 members. APS now has over 10,500 members. Most members have doctoral degrees in physiology and/or medicine (or other health professions). APS is governed by an elected Council consisting of a President, President-Elect, Past President, and nine Councillors. The National headquarters of the Society is based in Rockville, Maryland. 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M, 2001, Eur J Med Res, 6, 263",{},{"id":22,"text":1580,"url":22,"identifiers":1581},"Wostmann B, 1959, Am J Physiol, 197, 1345, 10.1152/ajplegacy.1959.197.6.1345",{"doi":1582},"10.1152/ajplegacy.1959.197.6.1345",{"id":22,"text":1584,"url":22,"identifiers":1585},"Wostmann BS, 1966, J Lipid Res, 7, 77, 10.1016/S0022-2275(20)39588-2",{"doi":1586},"10.1016/S0022-2275(20)39588-2",{"id":22,"text":1588,"url":22,"identifiers":1589},"10.1038/nature06005",{"doi":1588},{"id":22,"text":1591,"url":22,"identifiers":1592},"10.1073/pnas.1734063100",{"doi":1591},{"id":22,"text":1594,"url":22,"identifiers":1595},"10.1371/journal.pbio.0050156",{"doi":1594},{"id":22,"text":1597,"url":22,"identifiers":1598},"10.1271/bbb.80612",{"doi":1597},{"id":22,"text":1600,"url":22,"identifiers":1601},"10.1021/pr700864x",{"doi":1600},{"id":22,"text":1603,"url":22,"identifiers":1604},"10.1371/journal.ppat.0030035",{"doi":1603},{"id":22,"text":1606,"url":22,"identifiers":1607},"Zeuthen LH, 2008, Immunology, 123, 197",{},{"id":22,"text":1609,"url":22,"identifiers":1610},"10.1038/ismej.2009.112",{"doi":1609},{"id":22,"text":1612,"url":22,"identifiers":1613},"10.1111/j.1574-6941.2008.00604.x",{"doi":1612},{"id":22,"text":1615,"url":22,"identifiers":1616},"10.1111/j.1443-9573.2004.00157.x",{"doi":1615},{"id":22,"text":1618,"url":22,"identifiers":1619},"10.1080/089106001750462669",{"doi":1618},{"id":22,"text":1621,"url":22,"identifiers":1622},"10.1128/AEM.68.7.3401-3407.2002",{"doi":1621},{"id":1624,"createTime":1625,"updateTime":1626,"relativeEntities":1627,"slug":1628,"properties":1629,"entityType":242,"verifyStatus":382,"verifyTime":1625,"verifyNote":383,"syncStatus":384,"languages":1648,"translateLanguages":1649,"viewCount":23,"primaryUrl":1650,"fullTextUrl":22,"authors":1651,"publicationType":244,"publisherRelationship":1691,"citationCount":1744,"citationInfo":1745,"publishDate":22,"publishYear":22,"citationAnalyzeStatus":384,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":1753,"isForceReanalyzing":19},"bf8c1eb5-7a1c-4952-90e6-a1e8c8ba7663","2024-09-26T20:34:46.343+00:00","2024-12-29T14:32:12.322+00:00",[],"Effects-of-Probiotics-Prebiotics-and-Synbiotics-on-Human-Health",{"mag":1630,"keywords":1632,"pmc":1634,"openalex":1636,"abstract":1638,"title":1641,"pm":1644,"doi":1646},{"VOID":1631},"2755198076",{"VI":1633},"probiotics, prebiotics, synbiotics, sức khỏe con người, vi sinh vật đường ruột",{"VOID":1635},"5622781",{"VOID":1637},"W2755198076",{"EN":1639,"VI":1640},"\u003Cjats:p>The human gastrointestinal tract is colonised by a complex ecosystem of microorganisms. Intestinal bacteria are not only commensal, but they also undergo a synbiotic co-evolution along with their host. Beneficial intestinal bacteria have numerous and important functions, e.g., they produce various nutrients for their host, prevent infections caused by intestinal pathogens, and modulate a normal immunological response. Therefore, modification of the intestinal microbiota in order to achieve, restore, and maintain favourable balance in the ecosystem, and the activity of microorganisms present in the gastrointestinal tract is necessary for the improved health condition of the host. The introduction of probiotics, prebiotics, or synbiotics into human diet is favourable for the intestinal microbiota. They may be consumed in the form of raw vegetables and fruit, fermented pickles, or dairy products. Another source may be pharmaceutical formulas and functional food. This paper provides a review of available information and summarises the current knowledge on the effects of probiotics, prebiotics, and synbiotics on human health. The mechanism of beneficial action of those substances is discussed, and verified study results proving their efficacy in human nutrition are presented.\u003C/jats:p>","\u003Cjats:p>Đường tiêu hóa của con người được định cư bởi một hệ sinh thái phức tạp của các vi sinh vật. Vi khuẩn đường ruột không chỉ là vi khuẩn hội sinh, mà chúng còn trải qua quá trình đồng tiến hóa cùng với vật chủ của chúng. Các vi khuẩn đường ruột có lợi có nhiều chức năng quan trọng, ví dụ, chúng sản xuất nhiều chất dinh dưỡng cho vật chủ, ngăn chặn các nhiễm trùng do các tác nhân gây bệnh đường ruột và điều chỉnh phản ứng miễn dịch bình thường. Do đó, việc điều chỉnh vi sinh vật đường ruột nhằm đạt được, phục hồi và duy trì sự cân bằng có lợi trong hệ sinh thái, cũng như hoạt động của các vi sinh vật có mặt trong đường tiêu hóa là cần thiết cho tình trạng sức khỏe tốt hơn của vật chủ. Việc bổ sung probiotics, prebiotics hoặc synbiotics vào chế độ ăn uống của con người có lợi cho vi sinh vật đường ruột. Chúng có thể được tiêu thụ dưới dạng rau củ và trái cây tươi, dưa chua lên men hoặc sản phẩm từ sữa. Một nguồn khác có thể là các công thức dược phẩm và thực phẩm chức năng. Bài báo này cung cấp một cái nhìn tổng quan về thông tin hiện có và tóm tắt kiến thức hiện tại về tác động của probiotics, prebiotics và synbiotics đến sức khỏe con người. Cơ chế tác động có lợi của những chất này được thảo luận, và các kết quả nghiên cứu đã được xác minh chứng minh hiệu quả của chúng trong dinh dưỡng con người được trình bày.",{"EN":1642,"VI":1643},"Effects of Probiotics, Prebiotics, and Synbiotics on Human Health","Tác động của Probiotics, Prebiotics và Synbiotics đến Sức khỏe Con người",{"VOID":1645},"28914794",{"VOID":1647},"10.3390/nu9091021",[386],[388],"https://www.mdpi.com/2072-6643/9/9/1021",[1652,1674],{"id":1653,"sortIndex":23,"researcher":22,"roles":1654,"affiliations":1655,"properties":1667},"3c60924b-93e1-49e5-8660-7cfcbd702bd7",[],[1656],{"id":1657,"sortIndex":23,"affiliation":1658,"properties":22},"3cc8e73f-fa70-4965-8a76-bc1822639601",{"id":1659,"createTime":1660,"updateTime":1661,"relativeEntities":1662,"slug":1663,"properties":1664,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"359408bb-00db-4e01-a6c6-286a4874b8a1","2024-09-11T19:03:02.866+00:00","2024-09-26T20:34:46.363+00:00",[],"Institute-of-Fermentation-Technology-and-Microbiology-Department-of-Biotechnology-and-Food-Sciences-Lodz-University-of-Technology-90-924-%C5%81%C3%B3d%C5%BA-Poland",{"title":1665},{"EN":1666},"Institute of Fermentation Technology and Microbiology, Department of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Łódź, Poland",{"openalex":1668,"orcid":1670,"title":1672},{"VOID":1669},"A5021185901",{"VOID":1671},"https://orcid.org/0000-0001-9131-0546",{"EN":1673},"Paulina Markowiak‐Kopeć",{"id":1675,"sortIndex":148,"researcher":22,"roles":1676,"affiliations":1677,"properties":1684},"9e1343b8-36f3-49e1-a929-e713d80abbb1",[],[1678],{"id":1679,"sortIndex":23,"affiliation":1680,"properties":22},"8c1413ca-d61b-4fcd-9933-b6a28bc33974",{"id":1659,"createTime":1660,"updateTime":1661,"relativeEntities":1681,"slug":1663,"properties":1682,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1683},{"EN":1666},{"openalex":1685,"orcid":1687,"title":1689},{"VOID":1686},"A5025414387",{"VOID":1688},"https://orcid.org/0000-0002-3161-1707",{"EN":1690},"Katarzyna Śliżewska",{"url":22,"publisher":1692,"properties":1738},{"id":1693,"createTime":1694,"updateTime":1695,"relativeEntities":1696,"slug":1697,"properties":1698,"entityType":136,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1706,"manageAffiliations":1707,"indexDatabases":1708,"url":1731,"thumbnailPath":22,"statistic":1732,"gsStatistic":22,"type":22,"analyzePriority":22},"cc5862d2-36f8-482d-9ff1-df4716cfdc98","2023-05-29T12:02:19.788+00:00","2025-02-10T21:35:25.546+00:00",[],"Nutrients",{"country":1699,"issn":1701,"introduce":1703,"title":1705},{"VOID":1700},"CH",{"VOID":1702},"20726643",{"EN":1704},"Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for publishing studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files, software or other material, if unsuitable for publication as part of a manuscript, can be deposited as supplementary material. Nutrients will consider manuscripts for publication that provide novel insights into the impacts of nutrition on human health or novel methods for assessing nutritional status. This includes manuscripts describing the outcomes of animal studies that have relevance to human health. Manuscripts in the following subject areas will be considered for publication. 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Technol., 13, 121, 10.1016/S0924-2244(02)00129-2",{"doi":2543},"10.1016/S0924-2244(02)00129-2",{"id":2545,"createTime":2546,"updateTime":2547,"relativeEntities":2548,"slug":2549,"properties":2550,"entityType":242,"verifyStatus":382,"verifyTime":2546,"verifyNote":383,"syncStatus":384,"languages":2566,"translateLanguages":2567,"viewCount":23,"primaryUrl":2568,"fullTextUrl":22,"authors":2569,"publicationType":244,"publisherRelationship":2812,"citationCount":2861,"citationInfo":2862,"publishDate":2869,"publishYear":2870,"citationAnalyzeStatus":384,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":2871,"isForceReanalyzing":19},"e1c5363d-da3f-44e9-aa45-ce550258aa9b","2024-11-28T04:01:23.633+00:00","2025-01-07T05:33:59.352+00:00",[],"Gut-Microbiota-in-Health-Diverticular-Disease-Irritable-Bowel-Syndrome-and-Inflammatory-Bowel-Diseases-Time-for-Microbial-Marker-of-Gastrointestinal-Disorders",{"mag":2551,"keywords":2553,"openalex":2554,"abstract":2556,"title":2559,"pm":2562,"doi":2564},{"VOID":2552},"2724823319",{"VI":15},{"VOID":2555},"W2724823319",{"VI":2557,"EN":2558},"\u003Cjats:p>Có rất ít dữ liệu về sự khác biệt trong thành phần vi sinh vật đường ruột giữa các bệnh đường tiêu hóa chính. Chúng tôi đã đánh giá sự khác biệt trong thành phần vi sinh vật đường ruột giữa bệnh diverticular không biến chứng (DD), hội chứng ruột kích thích (IBS) và bệnh viêm ruột (IBD). Bệnh nhân DD, IBS và IBD cùng với những người khỏe mạnh (CT) đã được tuyển chọn vào phòng khám ngoại trú tiêu hóa của chúng tôi ở Ý. Mẫu phân đã được thu thập. Thành phần vi sinh vật được đánh giá thông qua phương pháp tiếp cận gen nhắm mục tiêu metagenomic. Bệnh lý tiêu hóa thể hiện một quang phổ liên tục của các bệnh, trong đó IBD thể hiện một cực đoan, trong khi CT thể hiện cực đối diện. Giữa các Phyla, đồ thị Biplot PC2/PC3 và đồ thị dendogram cho thấy sự khác biệt lớn trong các mẫu từ IBS và IBD. DD có thành phần tương tự với CT, nhưng không đối với \u003Ci>Bacteroides fragilis\u003C/i>. Trong IBS, \u003Ci>Dialister\u003C/i> spp. và sau đó là \u003Ci>Faecalibacterium prausnitzii\u003C/i> là các loài đại diện nhất. Viêm loét đại tràng cho thấy nồng độ \u003Ci>Clostridium difficile\u003C/i> giảm và nồng độ \u003Ci>Bacteroides fragilis\u003C/i> tăng. Trong bệnh Crohn, \u003Ci>Parabacteroides distasonis\u003C/i> là loài được đại diện nhiều nhất, trong khi \u003Ci>Faecalibacterium prausnitzii\u003C/i> và \u003Ci>Bacteroides fragilis\u003C/i> bị giảm đáng kể. Mỗi rối loạn có chữ ký vi sinh vật tổng thể riêng, tạo ra sự khác biệt rõ ràng so với các rối loạn khác. Mặt khác, những thay đổi chung tạo thành “dysbiosis lõi” của các bệnh đường tiêu hóa. Việc đánh giá những dấu hiệu vi sinh vật này đại diện cho một tham số có thể bổ sung cho việc đánh giá chẩn đoán.\u003C/jats:p>","\u003Cjats:p>Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) patients. DD, IBS, and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected. Microbiota composition was evaluated through a metagenomic gene-targeted approach. GI pathology represented a continuous spectrum of diseases where IBD displayed one extreme, while CT displayed the other. Among Phyla, Biplot PC2/PC3 and dendogram plot showed major differences in samples from IBS and IBD. DD resembled species CT composition, but not for &lt;i&gt;Bacteroides fragilis&lt;/i&gt;. In IBS, &lt;i&gt;Dialister&lt;/i&gt; spp. and then &lt;i&gt;Faecalibacterium prausnitzii&lt;/i&gt; were the most representative species. Ulcerative colitis showed a reduced concentration of &lt;i&gt;Clostridium difficile&lt;/i&gt; and an increase of &lt;i&gt;Bacteroides fragilis&lt;/i&gt;. In Crohn's disease, &lt;i&gt;Parabacteroides distasonis&lt;/i&gt; was the most represented, while &lt;i&gt;Faecalibacterium prausnitzii&lt;/i&gt; and &lt;i&gt;Bacteroides fragilis&lt;/i&gt; were significantly reduced. Each disorder has its definite overall microbial signature, which produces a clear differentiation from the others. On the other hand, shared alterations constitute the “core dysbiosis” of GI diseases. The assessment of these microbial markers represents a parameter that may complete the diagnostic assessment.\u003C/jats:p>",{"VI":2560,"EN":2561},"Vi sinh vật đường ruột trong sức khỏe, bệnh diverticular, hội chứng ruột kích thích và bệnh viêm ruột: Thời điểm cho dấu hiệu vi sinh vật của các rối loạn tiêu hóa","Gut Microbiota in Health, Diverticular Disease, Irritable Bowel Syndrome, and Inflammatory Bowel Diseases: Time for Microbial Marker of Gastrointestinal Disorders",{"VOID":2563},"28683448",{"VOID":2565},"10.1159/000477205",[386],[388],"https://karger.com/DDI/article/doi/10.1159/000477205",[2570,2592,2613,2631,2649,2666,2684,2701,2719,2737,2754,2772,2790],{"id":2571,"sortIndex":180,"researcher":22,"roles":2572,"affiliations":2573,"properties":2585},"d5ac0a8f-ebee-4d43-9975-b9c7dcf7d745",[],[2574],{"id":2575,"sortIndex":23,"affiliation":2576,"properties":22},"4db7d39e-7cb7-4845-8e4a-1a4a473c6adc",{"id":2577,"createTime":2578,"updateTime":2579,"relativeEntities":2580,"slug":2581,"properties":2582,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"a61e50f1-7f16-4e44-940e-d51acbe47700","2024-09-20T19:18:29.944+00:00","2024-11-28T04:01:23.715+00:00",[],"Institute-of-Microbiology-and",{"title":2583},{"EN":2584},"Institute of Microbiology and",{"openalex":2586,"orcid":2588,"title":2590},{"VOID":2587},"A5028440941",{"VOID":2589},"https://orcid.org/0000-0003-4708-1250",{"EN":2591},"Francesco Paroni Sterbini",{"id":2593,"sortIndex":157,"researcher":22,"roles":2594,"affiliations":2595,"properties":2606},"7536fab4-a130-45f4-95e2-dda1fadeeb7b",[],[2596],{"id":2597,"sortIndex":23,"affiliation":2598,"properties":22},"aad01831-9c2e-4aa7-bd28-7b417e57316d",{"id":2599,"createTime":2600,"updateTime":2600,"relativeEntities":2601,"slug":2602,"properties":2603,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"46921258-f3db-463f-b10e-4e5b55b70ce4","2024-11-28T04:01:23.652+00:00",[],"Department-of-Internal-Medicine-Gastroenterology-Division-",{"title":2604},{"EN":2605},"Department of Internal Medicine, Gastroenterology Division,",{"openalex":2607,"orcid":2609,"title":2611},{"VOID":2608},"A5055816097",{"VOID":2610},"https://orcid.org/0000-0003-3578-7571",{"EN":2612},"C. 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M, Midtvedt T, Uribe A (1994) Differential cell kinetics in the ileum and colon of germfree rats. Scand J Gastroenterol 29: 445–451\nBackhed F, Ding H, Wang T, et al. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101: 15718–15723\nBackhed F, Manchester JK, Semenkovich CF, Gordon JI (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci USA 104: 979–984\nCani PD, Delzenne NM (2009) Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol 9: 737–743\nChristl SU, Murgatroyd PR, Gibson GR, Cummings JH (1992) Production, metabolism, and excretion of hydrogen in the large intestine. Gastroenterology 102: 1269–1277\nCummings JH, Macfarlane GT (1991) The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 70: 443–459\nCummings JH, Macfarlane GT (1997) Colonic microflora: nutrition and health. Nutrition 13: 476–478\nDe La Cochetiere MF, Durand T, Lepage P, et al. (2005) Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge. J Clin Microbiol 43: 5588–5592\nEckburg PB, Bik EM, Bernstein CN, et al. (2005) Diversity of the human intestinal microbial flora. Science 308: 1635–1638\nFranks AH, Harmsen HJ, Raangs GC, et al. (1998) Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 64: 3336–3345\nGérard P (2009) GI tract: microbial metabolism of steroids. In: Timmis KN (ed) Microbiology of hydrocarbons, oils, lipids, and derived compounds, vol 4. Springer-Verlag GmbH, Heidelberg pp. 3133–3140\nGérard P, Lepercq P, Leclerc M, et al. (2007) Bacteroides sp. strain D8, the first cholesterol-reducing bacterium isolated from human feces. Appl Environ Microbiol 73: 5742–5749\nHayashi H, Sakamoto M, Benno Y (2002) Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods. Microbiol Immunol 46: 535–548\nHooper LV, Wong MH, Thelin A, et al. (2001) Molecular analysis of commensal host-microbial relationships in the intestine. Science 291: 881–884\nJuste C (2005) Acides gras alimentaires, flore intestinale et cancer. Bull Cancer 92: 708–721\nJaeger KE, Ransac S, Dijkstra BW, et al. (1994) Bacterial lipases. FEMS Microbiol Rev 15: 29–63\nMacfarlane GT, Cummings JH, Allison C (1986) Protein degradation by human intestinal bacteria. J Gen Microbiol 132: 1647–1656\nMacpherson AJ, Harris NL (2004) Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4: 478–485\nPalmer C, Bik EM, DiGiulio DB, et al. (2007) Development of the human infant intestinal microbiota. PLoS Biol 5: e177\nRabot S, Membrez M, Bruneau A, et al. (2010) Germfree C57BL/6J mice are resistant to high fat diet-induced insulin resistance and have altered cholesterol metabolism, FASEB J 24: 4948–4959\nShanahan F (2002) The host-microbe interface within the gut. Best Pract Res Clin Gastroenterol 16: 915–931\nTannock GW, Fuller R, Smith SL, Hall MA (1990) Plasmid profiling of members of the family Enterobacteriaceae, Lactobacilli, and Bifidobacteria to study the transmission of bacteria from mother to infant. J Clin Microbiol 28: 1225–1228\nTap J, Mondot S, Levenez F, et al. (2009) Towards the human intestinal microbiota phylogenetic core. Environ Microbiol 11: 2574–2584\nTurnbaugh PJ, Ley RE, Mahowald MA, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444: 1027–1031\nWostmann BS, Larkin C, Moriarty A, Bruckner-Kardoss E (1983) Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. Lab Anim Sci 33: 46–50\nZoetendal EG, Akkermans AD, De Vos WM (1998) Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 64: 3854–3859",{"EN":15,"VI":2963},"vi sinh vật đường ruột, chức năng chuyển hóa, hệ miễn dịch, sức khỏe",{"EN":2965,"VI":2966},"Le microbiote intestinal, dont la densité atteint son maximum dans le côlon (1011 bactéries par gramme), est composé de centaines d’espèces. Si ce profil d’espèces est spécifique de chaque individu, trois phyla (Firmicutes, Bacteroidetes, Actinobacteria) sont systématiquement retrouvés en dominance chez l’adulte. Ce microbiote est globalement stable dans le temps chez un adulte sain et retrouve son état initial suite à une perturbation. Il exerce, par ailleurs, de nombreuses fonctions, en particulier métaboliques, essentielles pour le maintien de la santé de l’hôte. Les micro-organismes qui le composent sont ainsi capables de convertir une grande variété de substrats (incluant glucides, protéines et lipides), générant une diversité de métabolites dont la plupart ont des effets bénéfiques pour la santé. Des études comparatives entre des animaux conventionnels et des animaux dépourvus de microbiote intestinal ont, de plus, permis de mettre en évidence l’influence exercée par ces micro-organismes sur le développement et la maturation du système immunitaire, la physiologie intestinale ou encore le stockage des graisses.","Hệ vi sinh vật đường ruột, với mật độ đạt tối đa trong đại tràng (10^11 vi khuẩn trên mỗi gram), bao gồm hàng trăm loài. Mặc dù hồ sơ các loài này là đặc trưng cho mỗi cá nhân, ba nhánh (Firmicutes, Bacteroidetes, Actinobacteria) thường xuyên được phát hiện chiếm ưu thế ở người trưởng thành. Hệ vi sinh vật này nói chung ổn định theo thời gian ở người trưởng thành khỏe mạnh và trở lại trạng thái ban đầu sau một sự xáo trộn. Nó cũng thực hiện nhiều chức năng, đặc biệt là chức năng chuyển hóa, thiết yếu cho việc duy trì sức khỏe của vật chủ. Các vi sinh vật cấu thành nên nó có khả năng chuyển đổi một loạt các nền tảng (bao gồm carbohydrate, protein và lipid), tạo ra một sự đa dạng các metabolite mà hầu hết đều có tác dụng tích cực đối với sức khỏe. Các nghiên cứu so sánh giữa động vật thông thường và động vật thiếu hệ vi sinh vật đường ruột đã cho thấy ảnh hưởng của những vi sinh vật này tới sự phát triển và trưởng thành của hệ thống miễn dịch, sinh lý đường ruột, cũng như sự tích trữ chất béo.",{"EN":2968,"VI":2969},"Le microbiote intestinal: composition et fonctions","Hệ vi sinh vật đường ruột: thành phần và chức năng",{"VOID":2971},"10.1007/s10298-011-0615-8",{"VOID":2973},"[\"6049499926210996275\"]","2024-04-30T01:18:52.908+00:00",[388],"https://link.springer.com/article/10.1007/s10298-011-0615-8",[2978],{"id":2979,"sortIndex":23,"researcher":22,"roles":2980,"affiliations":2982,"properties":2993},"4ed4cb5e-543a-4a78-ace9-299d8266074b",[2981],"AUTHOR",[2983],{"id":22,"sortIndex":23,"affiliation":2984,"properties":22},{"id":2985,"createTime":2986,"updateTime":2987,"relativeEntities":2988,"slug":2989,"properties":2990,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"e5cc8a1d-29a9-4333-8e7f-670ff8eb1212","2024-04-08T21:50:28.597+00:00","2024-06-15T22:34:43.408+00:00",[],"UMR-1319-Micalis-INRA-Jouy-en-Josas-France",{"title":2991},{"VI":2992},"UMR 1319 Micalis, INRA, Jouy-en-Josas, France",{"title":2994,"gsAuthor":2996},{"VI":2995},"P. Gérard",{"VOID":2997},"[\"1aUoTvcAAAAJ\"]",{"url":22,"publisher":2999,"properties":22},{"id":3000,"createTime":3001,"updateTime":3002,"relativeEntities":3003,"slug":3004,"properties":3005,"entityType":136,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":3010,"manageAffiliations":3011,"indexDatabases":3012,"url":22,"thumbnailPath":22,"statistic":3025,"gsStatistic":22,"type":3070,"analyzePriority":22},"c1d5538b-98c8-47f2-8332-eebc655466f3","2024-04-11T07:28:24.511+00:00","2025-01-14T07:21:09.736+00:00",[],"Phytoth%C3%A9rapie",{"issn":3006,"title":3008},{"VOID":3007},"17652847",{"VOID":3009},"Phytothérapie",[],[],[3013],{"id":3014,"indexDatabase":3015,"url":3020,"indexYears":3021,"academicFieldIds":3022},"8d54e4a8-7b27-42b8-b588-f2c76d351c00",{"id":487,"createTime":488,"updateTime":489,"relativeEntities":3016,"label":3017,"description":3018,"key":495,"publicationTags":3019,"standard":22},[],{"EN":492,"VI":492},{"EN":492,"VI":494},[497],"https://www.scopus.com/sourceid/130170","2005-2023",[3023,3024],"65857ef0-efca-4ddd-8d09-41c20c01c9e0","e39d1b91-b03d-48ed-87bb-ab5b714ad558",{"impactFactor":23,"impactFactorByYear":3026,"i10Index":3031,"i10IndexLast5Year":23,"totalPublication":3032,"totalPublicationByYear":3033,"totalCitation":3045,"totalCitationByYear":3046,"totalCitationPerPublication":3054,"totalCitationPerPublicationByYear":3055,"hindexLast5Year":2721,"hindex":2721},{"2012":3027,"2013":3028,"2014":3029,"2015":3030,"2016":3028,"2017":3027,"2018":3028},0.04,0.01,0.03,0.07,14,720,{"2004":3034,"2005":3035,"2006":3036,"2007":3037,"2008":3038,"2009":3039,"2010":3040,"2011":3037,"2012":3041,"2013":3042,"2014":3041,"2015":3043,"2016":3044,"2017":3038,"2018":2615},30,55,35,53,46,57,60,45,68,64,47,425,{"2004":180,"2005":3047,"2006":3048,"2007":3049,"2008":3050,"2009":3031,"2010":3051,"2011":3036,"2012":2864,"2013":1747,"2014":2866,"2015":3052,"2016":3053,"2017":2792},32,50,17,26,49,67,16,0.59,{"2004":3056,"2005":3057,"2006":3058,"2007":3059,"2008":3060,"2009":3061,"2010":3062,"2011":3063,"2012":3064,"2013":3065,"2014":3066,"2015":3067,"2016":3068,"2017":3069},0.13,0.58,1.43,0.32,0.57,0.25,0.82,0.66,0.44,0.76,0.49,1.05,0.34,0.11,"JOURNAL",{"total":2756,"publishYear":3072,"statisticByYear":3073},2011,{"2013":148,"2015":148,"2016":148,"2018":148,"2021":2792,"2022":148,"2024":157},"2011-03-18","ERROR_IN_ANALYZE_CITATION","2025-07-26T13:18:29.088+00:00",{"id":3078,"createTime":3079,"updateTime":3080,"relativeEntities":3081,"slug":3082,"properties":3083,"entityType":242,"verifyStatus":382,"verifyTime":3096,"verifyNote":383,"syncStatus":384,"languages":22,"translateLanguages":3097,"viewCount":23,"primaryUrl":3098,"fullTextUrl":22,"authors":3099,"publicationType":244,"publisherRelationship":3115,"citationCount":22,"citationInfo":22,"publishDate":3228,"publishYear":3229,"citationAnalyzeStatus":384,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":19},"43472562-f6d2-43bc-92c0-829648011201","2024-01-14T05:12:27.322+00:00","2025-01-01T22:21:04.278+00:00",[],"Graduate-public-health-training-in-healthcare-of-refugee-asylum-seekers-and-clinical-human-rights-evaluation-of-an-innovative-curriculum",{"references":3084,"abstract":3086,"title":3089,"doi":3092,"keywords":3094},{"VOID":3085},"American College of Physicians (1995) The role of the physician and the medical profession in the prevention of international torture and in the treatment of its survivors. Ann Intern Med 122(8):607–613\nAmnesty International (2012) Amnesty International Report. http://files.amnesty.org/air12/fnf_air_2012_en.pdf. Accessed 16 Aug 2014\nAsgary R (2013a) A call to teach medical students clinical human rights. Acad Med 88(3):298–299\nAsgary R (2013b) Bringing global health and global health education home. Acad Med 88(7):908\nAsgary R, Segar N (2011) Barriers to health care access among refugee asylum seekers. J Health Care Poor Underserved 22(2):506–522\nAsgary RG, Metalios EE, Smith CL, Paccione GA (2006) Evaluating asylum seekers/torture survivors in urban primary care: a collaborative approach at the Bronx Human Rights Clinic. Health Hum Rights 9(2):164–179\nAsgary R, Charpentier B, Burnett DC (2013a) Socio-medical challenges of asylum seekers prior and after coming to the US. J Immigr Minor Health 15(5):961–968\nAsgary R, Saenger P, Jophlin L, Burnett D (2013b) Domestic global health: a curriculum teaching medical students to evaluate refugee asylum seekers and torture survivors. Teach Learn Med 25(4):348–357\nAshcroft RE (2005) Standing up for the medical rights of asylum seekers. J Med Ethics 31(3):125–126\nAssociation of Schools of Public Health (2014) Competencies, learning outcomes, and critical educational elements. http://www.asph.org/document.cfm?page=1083. Accessed 14 Nov 2014\nAssociation of Schools of Public Health Education Committee (2006) Master’s degree in public health core competency model, version 2.3. ASPH, Washington\nBasoglu M (1993) Prevention of torture and care of survivors. an integrated approach. JAMA 270(5):606–611\nBertoncello C, Buja A, Silenzi A, Specchia ML, Franchino G, Lazzari A, Baldo V, Ricciardi W, Damiani G (2015) Good governance competencies in public health to train public health physicians. Int J Public Health. 60(6):737–749\nBischoff A, Bovier PA, Rrustemi I, Gariazzo F, Eytan A, Loutan L (2003) Language barriers between nurses and asylum seekers: their impact on symptom reporting and referral. Soc Sci Med 57(3):503–512\nCarinci AJ, Mehta P, Christo PJ (2010) Chronic pain in torture victims. Curr Pain Headache Rep 14(2):73–79\nDrain PK, Primack A, Hunt D, Fawzi WW, Holmes KK, Gardner P (2007) Global health in medical education: a call for more training and opportunities. Acad Med 82:226–230\nEmory KW, Evans D, Stephenson R, Del Rio C, Curran JW (2014) Incorporating global health competencies into the public health curriculum. Public Health Rep 129(2):203–208\nFarmer P (2005) Pathologies of power: health, human rights, and the new war on the poor. University of California Press, London\nFrançois G, Hambach R, van Sprundel M, Devillé W, Van Hal G (2008) Inspecting asylum seekers upon entry—a medico-ethical complex. Eur J Public Health 18(6):552–553\nGebbie K, Rosenstock L, Hernandez LM (eds) (2003) Who will keep the public healthy? Educating public health professionals for the 21st century. National Academies Press, Washington\nGodkin M, Savageau J (2003) The effect of medical students’ international experiences on attitudes toward serving underserved multicultural populations. Fam Med 35(4):273–278\nHeisler M, Moreno A, DeMonner S, Keller A, Iacopino V (2003) Assessment of torture and ill treatment of detainees in Mexico: attitudes and experiences of forensic physicians. JAMA 289(16):2135–2143\nIstanbul Protocol (2004) UN Office of High Commissioner for Human Rights, Manual on Effective Investigation and Documentation of Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment (IP). http://www.ohchr.org/documents/publications/training8rev1en.pdf. Accessed 11 Feb 2014\nMcNeill PM (2003) Public health ethics: asylum seekers and the case for political action. Bioethics 17(5–6):487–502\nO’Neil E (2006) Awakening hippocrates: a primer on health, poverty, and global service. AMA Press, Chicago, US\nPaccaud F, Weihofen A, Frank M (2013) Public health workforce in Switzerland: are public health workers lacking? Int J Public Health 58(6):799–800\nPadder FA (1995) Human rights and the medical profession. Ann Intern Med 123(8):636\nPanosian C, Coates TJ (2006) The new medical “missionaries”—grooming the next generation of global health workers. N Engl J Med 354(17):1771–1773. doi:10.1056/NEJMp068035\nParsi K, List J (2008) Preparing medical students for the world: service learning and global health justice. Medscape J Med 10(11):268\nPiwowarczyk L, Keane TM, Lincoln A (2008) Hunger: the silent epidemic among asylum seekers and resettled refugees. Int Migr 46(1):59–77\nSaulnier DD, Brolin K (2015) A systematic review of the health effect of prenatal exposure to disaster. Int J Public Health. Aug 23. doi:10.1007/s00038-015-0699-2\nSmith J, Roberts B, Knight A, Gosselin R, Blanchet K (2015) A systematic literature review of the quality of evidence for injury and rehabilitation interventions in humanitarian crises. Int J Public Health. Aug 23. doi:10.1007/s00038-015-0723-6\nSonis J, Gorenflo DW, Jha P, Williams C (1996) Teaching of human rights in US medical schools. JAMA 276(20):1676–1678\nThe Convention against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment (the “Torture Convention”) (1984) UN General Assembly. http://untreaty.un.org/cod/avl/ha/catcidtp/catcidtp.html. Accessed 11 Feb 2014\nUnited Nation High Commissioner for Refugees (UNHCR) (2010) Statistical Yearbook, Chapter 2. http://www.unhcr.org/4ef9c7849.html. Accessed 15 Nov 2014\nUnited States Census Bureau (2010). http://www.census.gov/prod/2010pubs/acsbr09-15.pdf. Accessed 11 Feb 2014\nVorbrüggen M, Baer HU (2007) Humiliation: the lasting effect of torture. Mil Med 172(12 Suppl):29–33\nVukovic D, Bjegovic-Mikanovic V, Otok R, Czabannowska K, Nikolic Z, Laaser U (2014) Which level of competence and performance is expected? A survey among European employers of public health professionals. Int J Public Health 59(1):15–30\nWenzel T (2007) Torture. Curr Opin Psychiatry 20(5):491–496\nWenzel T, Griengl H, Stompe T, Mirzaei S, Kieffer W (2000) Psychological disorders in survivors of torture: exhaustion, impairment and depression. Psychopathology 33(6):292–296\nWong EC, Marshall GN, Schell TL et al (2005) Barriers to mental health care utilization for US Cambodian refugees. J Consult Clin Psychol 74(6):1116–1120",{"VI":3087,"EN":3088},"Một chương trình giảng dạy đổi mới đã được phát triển để trang bị cho sinh viên sức khỏe cộng đồng những thái độ và kỹ năng phù hợp nhằm giải quyết vấn đề chăm sóc sức khỏe cho người xin tị nạn. Được triển khai vào năm 2005, chương trình giảng dạy bao gồm: (1) các buổi học lý thuyết bao gồm dịch tễ học và các di chứng sức khỏe của việc tra tấn, luật tị nạn và các phương pháp nhận diện nhu cầu chăm sóc sức khỏe của những người sống sót; (2) các cuộc thảo luận với những người sống sót và những người ủng hộ; và (3) tham gia vào quy trình pháp lý y tế của việc xin tị nạn. Các đánh giá phối hợp bằng phương pháp định tính và định lượng bao gồm bảng hỏi trước và sau khi kết thúc chương trình giảng dạy, đánh giá chính thức về chương trình giảng dạy, bài viết cuối khóa và thuyết trình. 125 sinh viên đã tham gia. Sinh viên cho thấy kiến thức cải thiện về các di chứng của sự lạm dụng và nhu cầu chăm sóc sức khỏe của những người sống sót (P \u003C 0.01), thái độ cải thiện khi làm việc với những người sống sót (P \u003C 0.05) và khả năng tự tin trong việc xác định các nhóm dễ bị tổn thương và giải quyết vấn đề chăm sóc sức khỏe cho những người sống sót (P \u003C 0.05). Sinh viên báo cáo tăng mong muốn theo đuổi sự nghiệp y tế toàn cầu và nhân quyền. Là một chương trình đào tạo về ủng hộ và năng lực văn hóa trong thực hành sức khỏe cộng đồng nhằm giải quyết vấn đề chăm sóc sức khỏe cho người tị nạn trong nước, chương trình giảng dạy này đã nhận được sự đón nhận tốt và hiệu quả, và sẽ giúp sinh viên phục vụ tốt hơn những nhóm dân cư tương tự khác. Các cơ hội giảng dạy y tế toàn cầu và quyền con người trên cơ sở trường hợp dân số trong nước nên được tận dụng hiệu quả để phát triển một lực lượng y tế toàn cầu được trang bị tốt.","An innovative curriculum was developed to equip public health students with appropriate attitude and skills to address healthcare of asylum seekers. Implemented in 2005 the curriculum included: (1) didactic sessions covering epidemiology and health sequelae of torture, asylum laws, and approaches to identify survivors’ healthcare needs; (2) panel discussions with survivors and advocates; and (3) participating in medico-legal process of asylum seeking. Complementary mixed methods evaluations included pre- and post-curriculum questionnaires, formal curriculum evaluations, final papers and oral presentations. 125 students participated. Students showed improved knowledge regrading sequelae of abuse and survivors’ healthcare needs (P \u003C 0.01), improved attitudes towards working with survivors (P \u003C 0.05) and self-efficacy in identifying at-risk populations and addressing healthcare of survivors (P \u003C 0.05). Students reported increased desire to pursue global health and human rights careers. As an advocacy and cultural competency training in public health practice addressing healthcare of refugees domestically, this curriculum was well received and effective, and will also help students better serve other similar populations. Population case-based domestic opportunities to teach global health and health and human rights should be effectively utilized to develop a well-equipped global health corps.",{"VI":3090,"EN":3091},"Đào tạo sau đại học về chăm sóc sức khỏe cho người tị nạn và quyền con người lâm sàng: đánh giá một chương trình giảng dạy đổi mới","Graduate public health training in healthcare of refugee asylum seekers and clinical human rights: evaluation of an innovative curriculum",{"VOID":3093},"10.1007/s00038-015-0754-z",{"VI":3095},"chương trình giảng dạy đổi mới, sức khỏe cộng đồng, người tị nạn, chăm sóc sức khỏe, quyền con người, đào tạo sinh viên, đánh giá chương trình, năng lực văn hóa","2024-12-31T05:20:53.967+00:00",[388],"https://link.springer.com/article/10.1007/s00038-015-0754-z",[3100],{"id":3101,"sortIndex":23,"researcher":22,"roles":3102,"affiliations":3103,"properties":3112},"fce009ed-564e-49c5-a008-a2467d026d8d",[2981],[3104],{"id":22,"sortIndex":23,"affiliation":3105,"properties":22},{"id":3106,"createTime":3107,"updateTime":3107,"relativeEntities":3108,"slug":22,"properties":3109,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"87d95554-beff-4bbf-acf0-d9c2d6476af3","2024-01-14T05:12:27.342+00:00",[],{"title":3110},{"VI":3111},"Departments of Population Health and Medicine, New York University School of Medicine, New York, USA",{"title":3113},{"VI":3114},"Ramin Asgary",{"url":3098,"publisher":3116,"properties":3223},{"id":3117,"createTime":3118,"updateTime":3119,"relativeEntities":3120,"slug":3121,"properties":3122,"entityType":136,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":3127,"manageAffiliations":3128,"indexDatabases":3129,"url":22,"thumbnailPath":22,"statistic":3168,"gsStatistic":22,"type":3070,"analyzePriority":22},"3259c6d7-b1bf-44d7-a46c-2a82331f067c","2024-04-08T11:38:07.012+00:00","2025-01-25T16:46:14.136+00:00",[],"International-Journal-of-Public-Health",{"issn":3123,"title":3125},{"VOID":3124},"16618564",{"EN":3126},"International Journal of Public Health",[],[],[3130,3142,3152],{"id":3131,"indexDatabase":3132,"url":3137,"indexYears":3138,"academicFieldIds":3139},"29406c76-111f-4843-ac84-3acfe330ebfc",{"id":487,"createTime":488,"updateTime":489,"relativeEntities":3133,"label":3134,"description":3135,"key":495,"publicationTags":3136,"standard":22},[],{"EN":492,"VI":492},{"EN":492,"VI":494},[497],"https://www.scopus.com/sourceid/5300152615","1997,2007-2023",[3140,3141],"21bbbc30-93dc-48d1-aa1d-fcbf4135e849","ee1b374e-bbdc-4b00-909a-c625e8ec640c",{"id":3143,"indexDatabase":3144,"url":3149,"indexYears":22,"academicFieldIds":3150},"17ab8789-1700-4481-9de6-a0b1a38d7a58",{"id":508,"createTime":509,"updateTime":510,"relativeEntities":3145,"label":3146,"description":3147,"key":517,"publicationTags":3148,"standard":22},[],{"EN":513,"VI":513},{"VI":515,"EN":516},[519,520],"https://mjl.clarivate.com/search-results?issn=1661-8556",[3151],"61a85c60-2368-4b5a-8324-de1dbb4521a5",{"id":3153,"indexDatabase":3154,"url":3149,"indexYears":22,"academicFieldIds":3167},"3b015e03-7481-46f8-bedf-04f58f574a6e",{"id":3155,"createTime":3156,"updateTime":3157,"relativeEntities":3158,"label":3159,"description":3161,"key":3164,"publicationTags":3165,"standard":22},"a8273be3-1221-4f26-949d-71dc71ff1fc3","2023-05-22T09:59:54.622+00:00","2025-01-14T09:58:17.815+00:00",[],{"EN":3160,"VI":3160},"ISI-SSCI - 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Mar Biol 108:349–360\nPodrug M, Raspor B (2009) Seasonal variation of the metal (Zn, Fe, Mn) and metallothionein concentrations in the liver cytosol of the European chub (Squalius cephalus L.). Environ Monit Assess 157:1–10\nPodrug M, Raspor B, Erk M, Dragun Z (2009) Protein and metal concentrations in two fractions of hepatic cytosol of the European chub (Squalius cephalus L.). Chemosphere 75:843–849\nPollock MS, Clarke LMJ, Dubé MG (2007) The effects of hypoxia on fishes: from ecological relevance to physiological effects. Environ Rev 15:1–14\nPulliainen E, Korhonen K (1990) Seasonal changes in condition indices in adult mature and non-maturing burbot, Lota lota (L.), in the north-eastern Bothnian Bay, northern Finland. J Fish Biol 36:251–259\nRandall DJ (1970) Gas exchange in fish. In: Hoar WS, Randall DJ (eds) Fish Physiology. Academic Press, London, pp 253–292\nRandall D (1982) The control of respiration and circulation in fish during exercise and hypoxia. 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Ecotoxicology 13:291–301\nSepúlveda MS, Johnson WE, Higman JC, Denslow ND, Schoeb TR, Gross TS (2002) An evaluation of biomarkers of reproductive function and potential contaminant effects in Florida largemouth bass (Micropterus salmoides floridanus) sampled from the St. Johns River. Sci Total Environ 289:133–144\nShang EHH (2006) Hypoxia affects sex differentiation and development, leading to a male-dominated population in zebrafish (Danio rerio). Environ Sci Technol 40:3118–3122\nSoimasuo MR, Aaltonen T, Nikinmaa M, Pellinen J, Ristola T, Oikari A (1995) Physiological toxicity of low-chlorine bleached pulp and paper mill effluent on whitefish (Coregonus lavaretus L. s.1): a laboratory exposure simulating lake pollution. Ecotox Safe 31:228–237\nSures B, Siddall R, Taraschewski H (1999) Parasites as accumulation indicators of heavy metal pollution. Parasitol Today 15:16–21\nTeskeredžić E, Teskeredžić Z, Tomec M, Kurtović B, Raspor B, Kapetanović D, Dragun Z, Vardić I, Valić D, Strižak Ž, Španović B, Šoštarić Vulić Z, Roman Z (2009) Programme for the monitoring of the freshwater fishery status in the year 2009 - Group D - Fishing area Sava; River Sutla. [In Croatian: Program praćenja stanja slatkovodnog ribarstva u 2009. godini - Grupa D - ribolovno područje Sava; rijeka Sutla]. Ruđer Bošković Institute, Zagreb\nTimmerman CM, Chapman LJ (2004) Hypoxia and interdemic variation in Poecilia latipinna. J Fish Biol 65:635–650\nTreer T, Safner R, Aničić I, Lovrinov M (1995) Fishery (In Croatian). Globus, Zagreb\nÜnver B (1998) An investigation on the reproduction properties of chub (Leuciscus cephalus L., 1758) in Lake Tödürge (Zara/Sivas). Turk J Zool 22:141–147\nvan Cleef KA, Kaplan LAE, Crivello JF (2000) The relationship between reproductive status and metallothionein mRNA expression in the common killifish, Fundulus heteroclitus. Environ Biol Fishes 57:97–105\nvan Dyk JC, Cochrane MJ, Wagenaar GM (2012) Liver histopathology of the sharptooth catfish Clarias gariepinus as a biomarker of aquatic pollution. Chemosphere 87:301–311\nVašák M (2005) Advances in metallothionein structure and functions. J Trace Elem Med Biol 19:13–17\nViarengo A, Burlando B, Dondero F, Marro A, Fabbri R (1999) Metallothionein as a tool in biomonitoring programmes. Biomarkers 4:455–466\nWeltzien F, Doving KB, Carr WES (1999) Avoidance reaction of yolk-sac larvae of the inland silverside Menidia beryllina (Atherinidae) to hypoxia. J Exp Biol 202:2869–2876\nWoo NYS, Wu RSS (1984) Changes in biochemical composition in the red grouper, Epinephelus akaara (Temminck and Schlegel), and the Black Sea bream, Mylio macrocephalus (Basilewsky), during hypoxic exposure. Comp Biochem Physiol A Physiol 77:475–482\nZorita I, Ortiz-Zarragoitia M, Apraiz I, Cancio I, Orbea A, Soto M, Marigómez I, Cajaraville MP (2008) Assessment of biological effects of environmental pollution along the NW Mediterranean Sea using red mullets as sentinel organisms. Environ Pollut 153:157–168",{"EN":3240,"VI":3241},"The assessment of general condition of fish in the moderately contaminated aquatic environment was performed on the European chub (Squalius cephalus) caught in September 2009 in the Sutla River in Croatia. Although increases of the contaminants in this river (trace and macro elements, bacteria), as well as physico-chemical changes (decreased oxygen saturation, increased conductivity), were still within the environmentally acceptable limits, their concurrent presence in the river water possibly could have induced stress in aquatic organisms. Several biometric parameters, metallothionein (MT), and total cytosolic protein concentrations in chub liver and gills were determined as indicators of chub condition. Microbiological and parasitological analyses were performed with the aim to evaluate chub predisposition for bacterial bioconcentration and parasitic infections. At upstream river sections with decreased oxygen saturation (∼50 %), decreased Fulton condition indices were observed (FCI: 0.94 g cm−3), whereas gonadosomatic (GSI: 2.4 %), hepatosomatic (HSI: 1.31 %), and gill indices (1.3 %) were increased compared to oxygen rich downstream river sections (dissolved oxygen ∼90 %; FCI: 1.02 g cm−3; GSI: 0.6 %; HIS: ∼1.08 %; gill index: 1.0 %). Slight increase of MT concentrations in both organs at upstream (gills: 1.67 mg g−1; liver: 1.63 mg g−1) compared to downstream sites (gills: 1.56 mg g−1; liver: 1.23 mg g−1), could not be explained by induction caused by increased metal levels in the river water, but presumably by physiological changes caused by general stress due to low oxygen saturation. In addition, at the sampling site characterized by inorganic and fecal contamination, increased incidence of bacterial bioconcentration in internal organs (liver, spleen, kidney) was observed, as well as decrease of intestinal parasitic infections, which is a common finding for metal-contaminated waters. Based on our results, it could be concluded that even moderate contamination of river water by multiple contaminants could result in unfavourable living conditions and cause detectable stress for aquatic organisms.","Việc đánh giá tình trạng chung của cá trong môi trường nước ô nhiễm vừa phải đã được thực hiện trên loài cá chub châu Âu (Squalius cephalus) được bắt vào tháng 9 năm 2009 tại sông Sutla ở Croatia. Mặc dù nồng độ ô nhiễm trong sông này (các yếu tố vi lượng và vĩ lượng, vi khuẩn), cũng như các thay đổi hóa lý (giảm độ bão hòa oxy, tăng độ dẫn điện), vẫn nằm trong giới hạn chấp nhận về môi trường, sự hiện diện đồng thời của chúng trong nước có thể đã kích thích căng thẳng cho các sinh vật thủy sinh. Một số tham số sinh trắc học, nồng độ metallothionein (MT), và tổng nồng độ protein tế bào chất trong gan và mang cá chub đã được xác định như là những chỉ số về tình trạng của chub. Các phân tích vi sinh vật học và ký sinh trùng học đã được thực hiện nhằm đánh giá sự dễ mắc bệnh vi khuẩn và nhiễm ký sinh trùng của chub. Tại các đoạn sông phía thượng nguồn có độ bão hòa oxy giảm (∼50%), các chỉ số tình trạng Fulton giảm (FCI: 0.94 g cm−3), trong khi các chỉ số sinh dục (GSI: 2.4%), sinh dục gan (HSI: 1.31%), và chỉ số mang (1.3%) tăng lên so với các đoạn sông phía hạ lưu giàu oxy (oxy hòa tan ∼90%; FCI: 1.02 g cm−3; GSI: 0.6%; HSI: ∼1.08%; chỉ số mang: 1.0%). Sự gia tăng nhẹ nồng độ MT trong cả hai cơ quan ở thượng nguồn (mang: 1.67 mg g−1; gan: 1.63 mg g−1) so với các vị trí hạ lưu (mang: 1.56 mg g−1; gan: 1.23 mg g−1) không thể được giải thích bằng sự kích thích do nồng độ kim loại tăng trong nước sông, mà có lẽ do những thay đổi sinh lý do căng thẳng chung do độ bão hòa oxy thấp. Ngoài ra, tại điểm mẫu được đặc trưng bởi ô nhiễm vô cơ và phân, đã quan sát thấy sự gia tăng tỷ lệ tập trung vi khuẩn trong các cơ quan nội tạng (gan, lá lách, thận), cũng như giảm nhiễm trùng ký sinh trùng đường ruột, điều này là một phát hiện phổ biến đối với nước bị ô nhiễm kim loại. Dựa trên các kết quả của chúng tôi, có thể kết luận rằng ngay cả sự ô nhiễm vừa phải của nước sông bởi nhiều chất ô nhiễm có thể dẫn đến điều kiện sống không thuận lợi và gây ra căng thẳng có thể phát hiện cho các sinh vật thủy sinh.",{"EN":3243,"VI":3244},"Assessment of general condition of fish inhabiting a moderately contaminated aquatic environment","Đánh giá tình trạng chung của cá sống trong môi trường nước bị ô nhiễm vừa phải",{"VOID":3246},"10.1007/s11356-013-1463-x",{"VI":3248},"Ô nhiễm môi trường, cá chub châu Âu, sinh học thủy sinh, chỉ số sức khỏe sinh vật, ô nhiễm vi sinh","2025-01-14T14:24:07.184+00:00",[388],"http://link.springer.com/10.1007/s11356-013-1463-x",[3253,3269,3285,3297,3309,3321,3333,3345,3357,3369],{"id":3254,"sortIndex":148,"researcher":22,"roles":3255,"affiliations":3256,"properties":3266},"da991492-1265-4454-98f8-a28a184eee20",[2981],[3257],{"id":22,"sortIndex":23,"affiliation":3258,"properties":22},{"id":3259,"createTime":3260,"updateTime":3260,"relativeEntities":3261,"slug":3262,"properties":3263,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"803a3c8f-823d-49b0-b0b9-bbdcf66324ea","2023-11-24T23:51:33.035+00:00",[],"Division-for-Marine-and-Environmental-Research-Laboratory-for-Biological-Effects-of-Metals-Ru%C4%91er-Bo%C5%A1kovi%C4%87-Institute-Zagreb-Croatia",{"title":3264},{"VI":3265},"Division for Marine and Environmental Research, Laboratory for Biological Effects of Metals, Ruđer Bošković Institute, Zagreb, Croatia",{"title":3267},{"VI":3268},"Vlatka Filipović Marijić",{"id":3270,"sortIndex":2633,"researcher":22,"roles":3271,"affiliations":3272,"properties":3282},"b152f8eb-b633-498d-acfc-4713cc049585",[2981],[3273],{"id":22,"sortIndex":23,"affiliation":3274,"properties":22},{"id":3275,"createTime":3276,"updateTime":3276,"relativeEntities":3277,"slug":3278,"properties":3279,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"1d06d3f3-236a-41f6-a7f5-0cef4ae8eab2","2023-11-25T04:32:36.639+00:00",[],"Division-for-Marine-and-Environmental-Research-Laboratory-for-Aquaculture-and-Pathology-of-Aquatic-Organisms-Ru%C4%91er-Bo%C5%A1kovi%C4%87-Institute-Zagreb-Croatia",{"title":3280},{"VI":3281},"Division for Marine and Environmental Research, Laboratory for Aquaculture and Pathology of Aquatic Organisms, Ruđer Bošković Institute, Zagreb, Croatia",{"title":3283},{"VI":3284},"Emin 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P., Gil, O., Ferreira, M., Vale, C., & Reis-Henriques, M. A. (2007). Depuration of PCBs and DDTs in mullet under captivity clean conditions. Chemosphere, 67(9), S58–S64. doi:10.1016/j.chemosphere.2006.05.091.\nANZECC & ARMCANZ (2000). Australian and New Zealand guidelines for fresh and marine water quality. National water quality management strategy no. 4. Australian and New Zealand Environment and Conservation Council and Agricultural and Resource Management Council of Australia and New Zealand. Canberra, ACT.\nBaird, D. J., & Burton, G. A., Jr. (Eds.). (2001). Ecological variability: Separating natural from anthropogenic causes of ecosystem impairment. Pensacola: SETAC Press.\nBarile, N. B., Scopa, M., Nerone, E., Mascilongo, G., Recchi, S., Cappabianca, S., et al. (2009). Study of the efficacy of a closed cycle depuration system on bivalve molluscs. Veterinaria Italiana, 45(4), 555–566.\nChaplin, J. A., Baudains, G. A., Gill, H. S., McCulloch, R., & Potter, I. C. (1998). 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The estuarine quality paradox, environmental homeostasis and the difficulty of detecting anthropogenic stress in naturally stressed areas. Marine Pollution Bulletin, 54, 640–645. doi:10.1006/ecss.2002.1031.\nFerreira, M., Moradas-Ferreira, P., & Reis-Henriques, M. A. (2006). The effect of long-term depuration on levels of oxidative stress biomarkers in mullets (Mugil cephalus) chronically exposed to contaminants. Marine Environmental Research, 64, 181–190. doi:10.1016/j.marenvres.2007.01.001.\nForan, J. A., & Ferenc, S. A. (Eds.). (1999). Multiple stressors in ecological risk and impact assessment: proceedings from the Pellston Workshop on Multiple Stressors in Ecological Risk and Impact Assessment; 13–18 September 1997. Pensacola: SETAC Press.\nFoulsham, G., Nice, H. E., Fisher, S., Mueller, J., Bartkow, M., & Komorova, T. (2009). A baseline study of organic contaminants in the Swan and Canning catchment drainage system using passive sampling devices. Perth, Western Australia: Department of Water. Water Science Technical Series Report No. 5. 41 p. Accessed 7 December 2009. http://www.water.wa.gov.ay/PublicationStore.first/89366.pdf.\nGreenstreet, S. P. R., & Rogers, S. I. (2006). Indicators of the health of the North Sea fish community: Identifying reference levels for an ecosystem approach to management. ICES Journal of Marine Science, 63(4), 573–593. doi:10.1016/j.icesjms.2005.12.009.\nHodson, P. V., Klopper-Sams, P. J., Munkittrick, K. R., Lockhart, W. L., Metner, D. A., Luxon, P. I., et al. (1991). Protocols for measuring mixed function oxygenases of fish liver. Quebec, Canada: Canadian Technical Report of Fisheries and Aquatic Sciences 1829. 51 p.\nKapustka, L. (2008). Limitations of the current practices used to perform ecological risk assessment. Integrated Environmental Assessment and Management, 4(3), 290–298.\nKrahn, M. M., Rhodes, L. D., Myers, M. S., Macleod, W. D., Jr., & Malins, D. C. (1986). Association between metabolites of aromatic compounds in bile and the occurrence of hepatic lesions in English sole (Parophrys vetulus) from Puget Sound, Washington. Archives of Environmental Contamination and Toxicology, 15, 61–67.\nLin, E. L. C., Cormier, S. M., & Torsella, J. A. (1996). Fish biliary polycyclic aromatic hydrocarbon metabolites estimated by fixed-wavelength fluorescence: Comparison with HPLC-fluorescent detection. Ecotoxicology and Environmental Safety, 35, 16–23.\nLobry, J., Lepage, M., & Rochard, E. (2006). From seasonal patterns to a reference situation in an estuarine environment: Example of the small fish and shrimp fauna of the Gironde estuary (SW France). Estuarine, Coastal and Shelf Science, 70(1–2), 239–250. doi:10.1016/j.ecss.2006.06.014.\nLowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein measurement with the folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.\nMartin, L. S., Nieto, S. R., & Sanders, B. M. (1996). Characterization of the cellular stress response in aquatic organisms. In G. K. Ostrander (Ed.), Techniques in Aquatic Toxicology (pp. 341–370). Boca Raton: CRC Press Inc.\nMcClain, W. R. (2000). Assessment of depuration system and duration on gut evacuation rate and mortality of red swamp crawfish. Aquaculture, 186(3–4), 267–278.\nNice, H. E. (2009). A baseline study of contaminants in the sediments of the Swan and Canning estuaries. Perth, Western Australia: Department of Water. Water Science Technical Series Report No. 6. 54 p. Accessed 30 March, 2009. http://www.water.wa.gov.au/PublicationsStore/first/83909.pdf.\nNice, H. E., Grassi, M., Foulsham, G., Morgan, B., Evans, S. J., & Robb, M. (2009). A baseline study of contaminants in the Swan and Canning catchment drainage system. Perth, Western Australia: Department of Water. Water Science Technical Series Report No. 3. 150 p. 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Responses to environmental stressors in an estuarine fish: Interacting stressors and the impacts of local adaptation. Journal of Thermal Biology, 32, 152–161. doi:10.1016/jtherbio.2007.01.012.\nShugart, L. R. (1996). Application of the alkaline unwinding assay to detect DNA strand breaks in aquatic species. In G. K. Ostrander (Ed.), Techniques in aquatic toxicology (pp. 205–218). Boca Raton: CRC Press Inc.\nSuter, G., Cormier, S., & Norton, S. (2007). Ecological epidemiology and causal analysis. In G. W. Suter II (Ed.), Ecological risk assessment (2nd ed., pp. 39–68). Boca Raton: CRC Press.\nThomson, C. E., Rose, T., & Robb, M. (2001). Seasonal water quality patterns in the Swan River Estuary, 1994–1998, Technical report. Perth, Western Australia: Swan River Trust. 29 p.\nTwomey, L., & John, J. (2001). Effects of rainfall and salt-wedge movement on phytoplankton succession in the Swan-Canning Estuary, Western Australia. Hydrological Processes, 15, 2655–2669. doi:10.1002/hyp. 287.\nWebb, D. (2005). Assessment of the health of the Swan-Canning River system using biochemical markers of exposure in fish. PhD Thesis [Online]. Curtin University of Technology, Perth, Western Australia. 253 p Available at: http://adt.curtin.edu.au/theses/available/adt-WCU20061204.135553/.\nWebb, D., & Gagnon, M. M. (2002). Biomarkers of exposure in fish inhabiting the Swan-Canning Estuary, Western Australia—A preliminary study. Journal of Aquatic Ecosystem Stress and Recovery, 9(4), 259–269. doi:10.1023/A:1024033700202.\nWebb, D., & Gagnon, M. M. (2007). Serum sorbitol dehydrogenase activity as an indicator of chemically induced liver damage in black bream (Acanthopagrus butcheri). Environmental Bioindicators, 2(3), 172–182. doi:10.1080/15555270701591006.\nWebb, D., & Gagnon, M. M. (2009). The value of stress protein 70 as an environmental biomarker of fish health under field conditions. Environmental Toxicology, 24, 287–295. doi:10.1002/tox.20432.\nWebb, D., Gagnon, M. M., & Rose, T. (2005a). Interannual variability in fish biomarkers in a contaminated temperate urban estuary. Ecotoxicology and Environmental Safety, 62(1), 53–65. doi:10.1016/j.ecoenv.2004.12.003.\nWebb, D., Gagnon, M. M., & Rose, T. (2005b). Interseasonal variability in biomarkers of exposure in fish inhabiting a southwestern Australian estuary. Environmental Toxicology, 20(5), 522–532. doi:10.1002/tox.20141.\nWebb, D., Gagnon, M. M., & Rose, T. (2005c). Metabolic enzyme activities in black bream (Acanthopagrus butcheri) from the Swan-Canning Estuary, Western Australia. Comparative Biochemistry and Physiology. C, 141(4), 356–365. doi:10.1016/j.cbpc.2005.07.010.\nWestbrook, S. J., Rayner, J. L., Davis, G. B., Clement, T. P., Bjerg, P. L., & Fisher, S. J. (2005). Interaction between shallow groundwater, saline surface water and contaminant discharge at a seasonally and tidally forced estuarine boundary. Journal of Hydrology, 302(1–4), 255–269. doi:10.1016/j.jhydrol.2004.07.007.",{"EN":3537,"VI":3538},"The whole of the Swan-Canning Estuary, in the south-west of Australia, is impacted by human activity, and the selection of a local reference site to assess the impact of environmental contamination on the health of biota is not possible. To determine whether fish depurated under laboratory conditions could be used as an alternative to a reference site; adult black bream (Acanthopagrus butcheri) were collected from the estuary and maintained in clean water (S24) for 3 months. A suite of biomarkers of fish health were assessed, and the results were compared with field-captured black bream from three sites within the estuary (Ascot, Claisebrook, and Riverton). Comparisons of a subset of biomarkers were also made between hatchery-bred juvenile fish and the depurated fish. Biomarker levels were up to 3.8 times higher in field captured fish compared with depurated fish, while DNA integrity was lower. EROD activity was comparable in the hatchery-bred black bream to the depurated fish while s-SDH levels were two times higher in the hatchery fish. From the results obtained, field-captured black bream depurated for 3 months are suitable to determine reference/baseline levels for biomarker of health studies in estuarine environments.","Toàn bộ khu vực cửa sông Swan-Canning, thuộc phía tây nam Australia, bị ảnh hưởng bởi hoạt động của con người, và việc chọn một địa điểm tham chiếu địa phương để đánh giá tác động của ô nhiễm môi trường đối với sức khỏe của sinh vật là không khả thi. Để xác định xem cá được xử lý trong điều kiện lab có thể được sử dụng như một sự thay thế cho một địa điểm tham chiếu hay không; cá bream đen trưởng thành (Acanthopagrus butcheri) đã được thu thập từ cửa sông và duy trì trong nước sạch (S24) trong 3 tháng. Một loạt các chỉ số sinh học về sức khỏe của cá đã được đánh giá, và kết quả được so sánh với cá bream đen được thu tại hiện trường từ ba địa điểm trong cửa sông (Ascot, Claisebrook và Riverton). So sánh giữa một tập hợp con các chỉ số sinh học cũng được thực hiện giữa cá giống được nuôi tại trại và cá đã được xử lý. Mức độ chỉ số sinh học cao hơn tới 3,8 lần ở cá được thu tại hiện trường so với cá đã được xử lý, trong khi tính toàn vẹn DNA thấp hơn. Hoạt động EROD tương đương ở cá bream đen nuôi tại trại so với cá đã được xử lý, trong khi mức độ s-SDH cao gấp hai lần ở cá nuôi tại trại. Từ kết quả thu được, cá bream đen được thu tại hiện trường và đã được xử lý trong 3 tháng là phù hợp để xác định mức độ tham chiếu/cơ bản cho các nghiên cứu chỉ số sinh học về sức khỏe trong môi trường cửa sông.",{"EN":3540,"VI":3541},"Depurated fish as an alternative reference for field-based biomarker monitoring","Cá được xử lý như một tham chiếu thay thế cho việc giám sát sinh trắc học tại hiện trường",{"VOID":3543},"10.1007/s10661-012-2635-8",{"VI":3545},"Cá bream đen, sinh trắc học, cửa sông, sức khỏe sinh vật, ô nhiễm môi 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Individual fertility assessment and pro-fertility counselling; should this be offered to women and men of reproductive age? Hum Reprod. 2015;30:9–15. https://doi.org/10.1093/humrep/deu305.\nHvidman HW, Petersen KB, Larsen EC, Macklon KT, Pinborg A, Nyboe AA. Individual fertility assessment and pro-fertility counselling; should this be offered to women and men of reproductive age? Hum Reprod (Oxford, England). 2015;30:9–15. https://doi.org/10.1093/humrep/deu305.\nMoreno I, Míguez-Forjan JM, Simón C. Artificial gametes from stem cells. Clin Exp Reprod Med. 2015;42:33–44. https://doi.org/10.5653/cerm.2015.42.2.33.\nTakahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–72. https://doi.org/10.1016/j.cell.2007.11.019.\nXiao G-Y, Liu IH, Cheng C-C, Chang C-C, Lee Y-H, Cheng WT-K, et al. Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy. PLoS One. 2014;9:e106538–e. https://doi.org/10.1371/journal.pone.0106538.\nJensen F, Willis MA, Albamonte MS, Espinosa MB, Vitullo AD. Naturally suppressed apoptosis prevents follicular atresia and oocyte reserve decline in the adult ovary of Lagostomus maximus (Rodentia, Caviomorpha). Reproduction. 2006;132(2):301-8. https://doi.org/10.1530/rep.1.01054.\nBhartiya D, Sharma D. Ovary does harbor stem cells - size of the cells matter! J Ovarian Res. 2020;13:39. https://doi.org/10.1186/s13048-020-00647-2.",{"VI":3731,"EN":3732},"Phụ nữ theo đuổi khả năng sinh sản ở độ tuổi cao ngày càng trở nên phổ biến. Kế hoạch hóa gia đình và giáo dục giới tính truyền thống thường tập trung vào việc ngừa thai và phòng ngừa các bệnh lây truyền qua đường tình dục. Hiện nay, cũng cần phải chú ý đến nhận thức về khả năng sinh sản và bảo tồn khả năng sinh sản. Bài viết này nhằm cập nhật những bằng chứng hiện có về lưu trữ trứng theo ý muốn, đồng thời nhấn mạnh sự cần thiết của giáo dục về khả năng sinh sản và tư vấn cá nhân hóa dựa trên bằng chứng. Một tìm kiếm điện tử kỹ lưỡng đã được thực hiện từ khi bắt đầu các cơ sở dữ liệu đến tháng 3 năm 2020 nhằm tóm tắt các bằng chứng hiện có về việc đông lạnh trứng theo ý muốn, lý do đằng sau việc sử dụng nó, tư vấn và giáo dục bệnh nhân, tỷ lệ thành công và các rủi ro liên quan, quy định, hiệu quả chi phí, tình trạng hiện tại và triển vọng tương lai. Tư vấn do bác sĩ dẫn dắt về lão hóa sinh sản và bảo tồn khả năng sinh sản thường bị bỏ qua. Lưu trữ trứng theo ý muốn không đảm bảo tỷ lệ sinh sống và câu trả lời về hiệu quả chi phí cần phải được cá nhân hóa. Các nghiên cứu hiện có về kết quả sản khoa và perinatal sau khi sử dụng đông lạnh trứng vẫn cho thấy sự yên tâm tính đến thời điểm hiện tại. Việc theo dõi liên tục các kết quả ngắn hạn và dài hạn, quy định thống nhất và tư vấn cá nhân hóa dựa trên bằng chứng là vô cùng quan trọng. Lưu trữ trứng theo ý muốn là một trong những khía cạnh gây tranh cãi nhất trong lĩnh vực sinh sản hỗ trợ, và có rất nhiều câu hỏi vẫn chưa có lời giải đáp. Tuy nhiên, phụ nữ ngày nay có tùy chọn này, điều mà trước đây không có.","Women who pursue fertility at an advanced age are increasingly common. Family planning and sexual education have traditionally focused on contraception and prevention of sexually transmitted diseases. A focus should now also be placed on fertility awareness and fertility preservation. This manuscript aims to give an update on the existing evidence around elective oocyte cryopreservation, also highlighting the need for fertility education and evidence-based, individualized counselling. A thorough electronic search was performed from the start of databases to March 2020 aiming to summarize the existing evidence around elective egg freezing, the logic behind its use, patient counselling and education, success rates and risks involved, regulation, cost-effectiveness, current status and future perspectives. Clinician-led counselling regarding reproductive aging and fertility preservation is often overlooked. Elective oocyte cryopreservation is not a guarantee of live birth, and the answer regarding cost-effectiveness needs to be individualized. The existing studies on obstetric and perinatal outcomes following the use of egg freezing are, until now, reassuring. Constant monitoring of short-term and long-term outcomes, uniform regulation and evidence-based, individualized counselling is of paramount importance. Elective oocyte cryopreservation is one of the most controversial aspects of the world of assisted reproduction, and a lot of questions remain unanswered. However, women today do have this option which was not available in the past. Elective oocyte cryopreservation for age-related fertility decline should be incorporated in women’s reproductive options to ensure informed decisions and reproductive autonomy.",{"VI":3734,"EN":3735},"Lưu trữ trứng theo ý muốn cho sự suy giảm khả năng sinh sản liên quan đến độ tuổi","Elective oocyte cryopreservation for age-related fertility decline",{"VOID":3737},"10.1007/s10815-021-02072-w",{"VI":3739},"lưu trữ trứng; khả năng sinh sản; giáo dục sức khỏe; tư vấn cá nhân hóa; hiệu quả chi phí; lão hóa sinh sản","2025-01-22T23:32:03.761+00:00",[388],"https://link.springer.com/article/10.1007/s10815-021-02072-w",[3744,3759,3771,3795,3807],{"id":3745,"sortIndex":157,"researcher":22,"roles":3746,"affiliations":3747,"properties":3756},"7f60a1d3-f30d-462d-8ce1-0f0eb7efbe07",[2981],[3748],{"id":22,"sortIndex":23,"affiliation":3749,"properties":22},{"id":3750,"createTime":3751,"updateTime":3751,"relativeEntities":3752,"slug":22,"properties":3753,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"50dc5a36-fcf7-46c0-852e-cae42192e371","2024-02-10T22:26:31.112+00:00",[],{"title":3754},{"VI":3755},"Homerton Fertility Centre, Homerton University Hospital, London, UK",{"title":3757},{"VI":3758},"A. Sfakianakis",{"id":3760,"sortIndex":167,"researcher":22,"roles":3761,"affiliations":3762,"properties":3768},"15c90ddf-efd5-4387-bf0d-e7f36799c7ea",[2981],[3763],{"id":22,"sortIndex":23,"affiliation":3764,"properties":22},{"id":3750,"createTime":3751,"updateTime":3751,"relativeEntities":3765,"slug":22,"properties":3766,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":3767},{"VI":3755},{"title":3769},{"VI":3770},"G. 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J Pharm Pharm Sci 19:339–348\nFarshadzadeh Z, Hashemi FB, Rahimi S, Pourakbari B, Esmaeili D, Haghighi MA, Majidpour A, Shojaa S, Rahmani M, Gharesi S, Aziemzadeh M, Bahador A (2015) Wide distribution of carbapenem resistant Acinetobacter Baumannii in burns patients in Iran. Front Microbiol 6:1146\nBahador A, Raoo An R, Farshadzadeh Z, Beitollahi L, Khaledi A, Rahimi S, Mokhtaran M, Mehrabi Tavana A, Esmaeili D (2015) The prevalence of IS Aba 1 and IS Aba 4 in Acinetobacter Baumannii species of different international clone lineages among patients with burning in Tehran, Iran. Jundishapur J Microbiol 8:e17167\nMahdian S, Sadeghifard N, Pakzad I, Ghanbari F, Soroush S, Azimi L, Rastegar-Lari A, Giannouli M, Taherikalani M (2015) Acinetobacter Baumannii clonal lineages I and II harboring different carbapenem-hydrolyzing-beta-lactamase genes are widespread among hospitalized burn patients in Tehran. J Infect Public Health 8:533–542\nAzimi L, Talebi M, Pourshafie MR, Owlia P, Rastegar Lari A (2015) Characterization of Carbapenemases in extensively drug resistance Acinetobacter baumannii in a burn care center in Iran. Int J Mol Cell Med 4:46–53\nSalimizand H, Noori N, Meshkat Z, Ghazvini K, Amel SJ (2015) Prevalence of Acinetobacter Baumannii harboring ISAba1/bla OXA-23-like family in a burn center. Burns 41:1100–1106\nNasrolahei M, Zahedi B, Bahador A, Saghi H, Kholdi S, Jalalvand N, Esmaeili D (2014) Distribution of bla(OXA-23), ISAba , Aminoglycosides resistant genes among burned & ICU patients in Tehran and Sari, Iran. Ann Clin Microbiol Antimicrob 13:0\nPajand O, Rezaee MA, Nahaei MR, Mahdian R, Aghazadeh M, Soroush MH, Tabrizi MS, Hojabri Z (2013) Study of the carbapenem resistance mechanisms in clinical isolates of Acinetobacter baumannii: Comparison of burn and non-burn strains. Burns 39:1414–1419\nAzimi L, Talebi M, Khodaei F, Najafi M, Lari AR (2016) Comparison of multiple-locus variable-number tandem-repeat analysis with pulsed-field gel electrophoresis typing of carbapenemases producing Acinetobacter baumannii isolated from burn patients. Burns 42:441–445\nAzimi L, Lari AR, Talebi M, Owlia P, Alaghehbandan R, Asghari B, Lari ER (2015) Inhibitory-based method for detection of Klebsiella Pneumoniae carbapenemase Acinetobacter baumannii isolated from burn patients. Indian J Pathol Microbiol 58:192–195\nAzimi L, Rastegar Lari A, Alaghehbandan R, Alinejad F, Mohammadpoor M, Rahbar M (2012) KPC-producer gram negative bacteria among burned infants in Motahari hospital, Tehran: First report from Iran. Ann Burns Fire Disasters 25:74–77\nRadan M, Moniri R, Khorshidi A, Gilasi H, Norouzi Z, Beigi F, Dasteh Goli Y (2016) Emerging Carbapenem-resistant Pseudomonas aeruginosa isolates carrying blaIMP among burn patients in Isfahan, Iran. Arch Trauma Res 5:e33664\nFarajzadeh Sheikh A, Rostami S, Jolodar A, Tabatabaiefar MA, Khorvash F, Saki A, Shoja S, Sheikhi R (2014) Detection of metallo-beta lactamases among carbapenem-resistant Pseudomonas aeruginosa. Jundishapur J Microbiol 7:e12289\nSalimi F, Eftekhar F (2014) Prevalence of blaIMP, and blaVIM gene carriage in metallo-beta-lactamase-producing burn isolates of Pseudomonas aeruginosa in Tehran. Turk J Med Sci 44:511–514\nNeyestanaki DK, Mirsalehian A, Rezagholizadeh F, Jabalameli F, Taherikalani M, Emaneini M (2014) Determination of extended spectrum beta-lactamases, metallo-beta-lactamases and AmpC-beta-lactamases among carbapenem resistant Pseudomonas Aeruginosa isolated from burn patients. Burns 40:1556–1561\nLari AR, Azimi L, Rahbar M, Alaghehbandan R, Sattarzadeh-Tabrizi M (2014) First report of Klebsiella pneumonia carbapenemase-producing Pseudomonas aeruginosa isolated from burn patients in Iran: phenotypic and genotypic methods. GMS Hyg Infect Control 9:Doc06\nYousefi S, Nahaei M, Farajnia S, Ghojazadeh M, Akhi M, Sharifi Y, Milani M, Ghotaslou R (2010) Class 1 integron and Imipenem resistance in clinical isolates of Pseudomonas aeruginosa: Prevalence and antibiotic susceptibility. Iran J Microbiol 2:115–121\nEftekhar F, Naseh Z (2015) Extended-spectrum beta-lactamase and carbapenemase production among burn and non-burn clinical isolates of Klebsiella Pneumoniae. Iran J Microbiol 7:144–149\nRastegar Lari A, Azimi L, Rahbar M, Fallah F, Alaghehbandan R (2013) Phenotypic detection of Klebsiella Pneumoniae carbapenemase among burns patients: First report from Iran. Burns 39:174–176\nBenenson S, Navon-Venezia S, Carmeli Y, Adler A, Strahilevitz J, Moses AE, Block C (2009) Carbapenem-resistant Klebsiella Pneumoniae endocarditis in a young adult. Successful treatment with gentamicin and colistin. Int J Infect Dis 13:295\nCasini B, Selvi C, Cristina ML, Totaro M, Costa AL, Valentini P, Barnini S, Baggiani A, Tagliaferri E, Privitera G (2017) Evaluation of a modified cleaning procedure in the prevention of carbapenem-resistant Acinetobacter Baumannii clonal spread in a burn intensive care unit using a high-sensitivity luminometer. J Hosp Infect 95:46–52\nMathlouthi N, El Salabi AA, Ben Jomaa-Jemili M, Bakour S, Al-Bayssari C, Zorgani AA, Kraiema A, Elahmer O, Okdah L, Rolain JM, Chouchani C (2016) Early detection of metallo-beta-lactamase NDM-1- and OXA-23 carbapenemase-producing Acinetobacter Baumannii in Libyan hospitals. Int J Antimicrob Agents 48:46–50\nBaljin B, Baldan G, Chimeddorj B, Tulgaa K, Gunchin B, Sandag T, Pfeffer K, MacKenzie CR, Wendel AF (2016) Faecal carriage of gram-negative multidrug-resistant bacteria among patients hospitalized in two centres in Ulaanbaatar, Mongolia. PLoS One 11:e0168146\nSepehri S, Poliquin G, Alfattoh N, Boyd D, Mulvey M, Denisuik A, Fanella S, Karlowsky J, Walkty A (2014) Osteomyelitis due to multiple carbapenemase-producing gram-negative bacteria: the first case report of a GES-13-producing Pseudomonas aeruginosa isolate in Canada. Can J Infect Dis Med Microbiol 25:229–231\nNowak P, Paluchowska P, Budak A (2012) Distribution of blaOXA genes among carbapenem-resistant Acinetobacter Baumannii nosocomial strains in Poland. New Microbiol 35:317–325\nGarvey MI, Bradley CW, Jumaa P (2016) Environmental decontamination following occupancy of a burns patient with multiple carbapenemase-producing organisms. J Hosp Infect 93:136–140\nMaillet M, Pelloux I, Forli A, Vancoetsem K, Cheong Sing JS, Marfaing S, Ducki S, Batailler P, Mallaret MR (2014) Nosocomial transmission of carbapenem-resistant Pseudomonas Aeruginosa among burn patients. Infect Control Hosp Epidemiol 35:597–599\nBelotti PT, Thabet L, Laffargue A, Andre C, Coulange-Mayonnove L, Arpin C, Messadi A, M'Zali F, Quentin C, Dubois V (2015) Description of an original integron encompassing blaVIM-2, qnrVC1 and genes encoding bacterial group II intron proteins in Pseudomonas Aeruginosa. J Antimicrob Chemother 70:2237–2240\nZoghlami A, Kanzari L, Boukadida J, Messadi AA, Ghanem A (2012) Epidemiological profile and antibiotic resistance of Pseudomonas aeruginosa isolates in burn and traumatology center in Tunisia over a three-year period. Tunis Med 90:803–806\nAltoparlak U, Aktas F, Celebi D, Ozkurt Z, Akcay MN (2005) Prevalence of metallo-beta-lactamase among Pseudomonas aeruginosa and Acinetobacter baumannii isolated from burn wounds and in vitro activities of antibiotic combinations against these isolates. Burns 31:707–710\nKanamori H, Parobek CM, Juliano JJ, van Duin D, Cairns BA, Weber DJ, Rutala WA (2017) A prolonged outbreak of KPC-3-producing Enterobacter cloacae and Klebsiella pneumoniae driven by multiple mechanisms of resistance transmission at a large academic burn center. Antimicrob Agents Chemother 61:16\nRosenberger LH, Hranjec T, Politano AD, Swenson BR, Metzger R, Bonatti H, Sawyer RG (2011) Effective cohorting and \"superisolation\" in a single intensive care unit in response to an outbreak of diverse multi-drug-resistant organisms. Surg Infect 12:345–350\nMunoz-Price L, Zembower T, Penugonda S, Schreckenberger P, Lavin MA, Welbel S, Vais D, Baig M, Mohapatra S, Quinn JP, Weinstein RA (2010) Clinical outcomes of carbapenem-resistant Acinetobacter baumannii bloodstream infections: Study of a 2-state monoclonal outbreak. Infect Control Hosp Epidemiol 31:1057–1062\nFrench CE, Coope C, Conway L, Higgins JP, McCulloch J, Okoli G, Patel BC, Oliver I (2017) Control of carbapenemase-producing Enterobacteriaceae outbreaks in acute settings: An evidence review. J Hosp Infect 95:3–45\nBorer A, Eskira S, Nativ R, Saidel-Odes L, Riesenberg K, Livshiz-Riven I, Schlaeffer F, Sherf M, Peled N (2011) A multifaceted intervention strategy for eradication of a hospital-wide outbreak caused by carbapenem-resistant Klebsiella pneumoniae in southern Israel. Infect Control Hosp Epidemiol 32:1158–1165\nEnfield KB, Huq NN, Gosseling MF, Low DJ, Hazen KC, Toney DM, Slitt G, Zapata HJ, Cox HL, Lewis JD, Kundzins JR, Mathers AJ, Sifri CD (2014) Control of simultaneous outbreaks of carbapenemase-producing enterobacteriaceae and extensively drug-resistant Acinetobacter baumannii infection in an intensive care unit using interventions promoted in the Centers for Disease Control and Prevention 2012 carbapenemase-resistant Enterobacteriaceae toolkit. Infect Control Hosp Epidemiol 35:810–817\nMerchant N, Smith K, Jeschke MG (2015) An ounce of prevention saves tons of lives: infection in burns. Surg Infect 16:380–387",{"EN":3969,"VI":3970},"Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control. We evaluated CPMO-carriage and wound colonization in a burn patient initially treated in Romania, and transported to the Netherlands. The sequence types and acquired beta-lactamase genes of highly-resistant microorganisms were derived from next generation sequencing data. Next, we searched literature for reports on CPMOs in burn patients. Five different carbapenemase-producing isolates were cultured: two unrelated OXA-48-producing Klebsiella pneumoniae isolates, OXA-23-producing Acinetobacter baumanii, OXA-48-producing Enterobacter cloacae, and NDM-1-producing Providencia stuartii. Also, multi-drug resistant Pseudomonas aeruginosa isolates were detected. Among the sampling sites, there was high variety in CPMOs. We found 46 reports on CPMOs in burn patients. We listed the epidemiology of CPMOs by country of initial treatment, and summarized recommendations for care of these patients based on these reports and our study.","Chăm sóc sức khỏe cho bệnh nhân bỏng nặng là rất chuyên biệt và có thể cần chuyển giao bệnh nhân quốc tế. Bệnh nhân bỏng có nguy cơ cao phát triển nhiễm trùng. Những bệnh nhân đã được nhập viện ở các quốc gia mà các vi sinh vật sản xuất carbapenemase (CPMO) đang lưu hành có thể phát triển những nhiễm trùng khó điều trị. Ngoài ra, có nguy cơ bùng phát CPMOs trong các trung tâm điều trị bỏng. Nghiên cứu này nhấn mạnh rằng bệnh nhân bỏng có thể bị thuộc địa hóa nhiều bởi CPMOs, và cung cấp những khuyến nghị thực hành tốt nhất liên quan đến vi sinh học lâm sàng và kiểm soát nhiễm trùng. Chúng tôi đã đánh giá tình trạng mang CPMO và thuộc địa hóa vết thương ở một bệnh nhân bỏng ban đầu được điều trị ở Romania và được chuyển đến Hà Lan. Các kiểu chuỗi và gen beta-lactamase đã thu được của các vi sinh vật kháng thuốc cao được trích xuất từ dữ liệu giải trình tự thế hệ tiếp theo. Sau đó, chúng tôi đã tìm kiếm tài liệu về các báo cáo liên quan đến CPMOs ở bệnh nhân bỏng. Năm loại vi sinh vật sản xuất carbapenemase khác nhau đã được nuôi cấy: hai chủng Klebsiella pneumoniae sản xuất OXA-48 không có liên quan, Acinetobacter baumannii sản xuất OXA-23, Enterobacter cloacae sản xuất OXA-48, và Providencia stuartii sản xuất NDM-1. Ngoài ra, các chủng Pseudomonas aeruginosa kháng nhiều loại thuốc cũng đã được phát hiện. Giữa các địa điểm lấy mẫu, có sự đa dạng cao về CPMOs. Chúng tôi tìm thấy 46 báo cáo về CPMOs ở bệnh nhân bỏng. Chúng tôi đã liệt kê dịch tễ học của CPMOs theo quốc gia điều trị ban đầu, và tóm tắt các khuyến nghị cho việc chăm sóc những bệnh nhân này dựa trên những báo cáo đó và nghiên cứu của chúng tôi.",{"EN":3972,"VI":3973},"Extensive colonization with carbapenemase-producing microorganisms in Romanian burn patients: infectious consequences from the Colectiv fire disaster","Sự thuộc địa hóa rộng rãi với các vi sinh vật sản xuất carbapenemase ở bệnh nhân bỏng Romania: Những hậu quả nhiễm trùng từ thảm họa hỏa hoạn Colectiv",{"VOID":3975},"10.1007/s10096-017-3118-1",{"VI":3977},"bệnh nhân bỏng, vi sinh vật sản xuất carbapenemase, chăm sóc sức khỏe, kiểm soát nhiễm trùng, dịch tễ học","2025-02-05T15:06:30.202+00:00",[388],"https://link.springer.com/article/10.1007/s10096-017-3118-1",[3982,3997,4012,4029,4056,4068,4080,4099],{"id":3983,"sortIndex":180,"researcher":22,"roles":3984,"affiliations":3985,"properties":3994},"d32e2ee7-2418-4cfb-8d0d-a34bc5c0c1e2",[2981],[3986],{"id":22,"sortIndex":23,"affiliation":3987,"properties":22},{"id":3988,"createTime":3989,"updateTime":3989,"relativeEntities":3990,"slug":22,"properties":3991,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"c2a9be01-30a6-4d24-96d1-726464f8933f","2024-01-11T12:29:20.991+00:00",[],{"title":3992},{"VI":3993},"Burn Centre, Martini Hospital, Groningen, The Netherlands",{"title":3995},{"VI":3996},"G. I. J. M. Beerthuizen",{"id":3998,"sortIndex":2792,"researcher":22,"roles":3999,"affiliations":4000,"properties":4009},"0584ce14-aee4-4c37-bc1e-7a978a2c5253",[2981],[4001],{"id":22,"sortIndex":23,"affiliation":4002,"properties":22},{"id":4003,"createTime":4004,"updateTime":4004,"relativeEntities":4005,"slug":22,"properties":4006,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"35bebda4-9e3c-4903-b53b-ced94b8704d5","2024-01-09T15:18:42.640+00:00",[],{"title":4007},{"VI":4008},"Association of Dutch Burn Centers, Burn Centre, Martini Hospital Groningen, Groningen, The Netherlands",{"title":4010},{"VI":4011},"M. K. Nieuwenhuis",{"id":4013,"sortIndex":23,"researcher":22,"roles":4014,"affiliations":4015,"properties":4026},"bd495133-60c8-422c-a67f-26bb530e2c89",[2981],[4016],{"id":22,"sortIndex":23,"affiliation":4017,"properties":22},{"id":4018,"createTime":4019,"updateTime":4020,"relativeEntities":4021,"slug":4022,"properties":4023,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"596f1dfc-1b18-4d75-983f-240426b8f479","2024-01-05T17:57:33.351+00:00","2024-11-26T21:43:30.521+00:00",[],"Department-of-Medical-Microbiology-University-of-Groningen-University-Medical-Center-Groningen-Groningen-the-Netherlands",{"title":4024},{"VI":4025},"Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands",{"title":4027},{"VI":4028},"L. E. Pirii",{"id":4030,"sortIndex":167,"researcher":22,"roles":4031,"affiliations":4032,"properties":4053},"94382ba8-749f-4fa9-9315-ed9dfe1f8376",[2981],[4033,4043],{"id":22,"sortIndex":23,"affiliation":4034,"properties":22},{"id":4035,"createTime":4036,"updateTime":4037,"relativeEntities":4038,"slug":4039,"properties":4040,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"03e9d8f7-58c3-4c88-afa7-ef92baac8bef","2024-01-04T22:12:26.879+00:00","2025-06-11T17:13:17.932+00:00",[],"Department-of-Medical-Microbiology-Certe-Groningen-The-Netherlands",{"title":4041},{"VI":4042},"Department of Medical Microbiology, Certe, Groningen, The Netherlands",{"id":4044,"sortIndex":148,"affiliation":4045,"properties":4052},"a10af447-f0e7-48e8-8dc3-e5af5bcc8e7f",{"id":4046,"createTime":4047,"updateTime":4047,"relativeEntities":4048,"slug":22,"properties":4049,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},"d56e06a1-fe6b-4e70-9616-5c163344768c","2024-01-04T22:12:26.800+00:00",[],{"title":4050},{"VI":4051},"Department of Medical Microbiology, Martini Hospital, Groningen, The Netherlands",{},{"title":4054},{"VI":4055},"W. Vogels",{"id":4057,"sortIndex":148,"researcher":22,"roles":4058,"affiliations":4059,"properties":4065},"8106091f-b31f-4ce4-b9b5-9391748c6d35",[2981],[4060],{"id":22,"sortIndex":23,"affiliation":4061,"properties":22},{"id":4018,"createTime":4019,"updateTime":4020,"relativeEntities":4062,"slug":4022,"properties":4063,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":4064},{"VI":4025},{"title":4066},{"VI":4067},"A. W. Friedrich",{"id":4069,"sortIndex":2774,"researcher":22,"roles":4070,"affiliations":4071,"properties":4077},"38a1ebb8-462e-44d8-9783-b0334405349a",[2981],[4072],{"id":22,"sortIndex":23,"affiliation":4073,"properties":22},{"id":4018,"createTime":4019,"updateTime":4020,"relativeEntities":4074,"slug":4022,"properties":4075,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":4076},{"VI":4025},{"title":4078},{"VI":4079},"E. Bathoorn",{"id":4081,"sortIndex":2668,"researcher":22,"roles":4082,"affiliations":4083,"properties":4096},"afa5ed83-5f0b-4377-9af8-53b431f1f917",[2981],[4084,4089],{"id":22,"sortIndex":23,"affiliation":4085,"properties":22},{"id":4018,"createTime":4019,"updateTime":4020,"relativeEntities":4086,"slug":4022,"properties":4087,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":4088},{"VI":4025},{"id":4090,"sortIndex":148,"affiliation":4091,"properties":4095},"ffa222f8-a284-4897-98a9-4f4acdb0f353",{"id":4035,"createTime":4036,"updateTime":4037,"relativeEntities":4092,"slug":4039,"properties":4093,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":4094},{"VI":4042},{},{"title":4097},{"VI":4098},"A. M. D. Kooistra-Smid",{"id":4100,"sortIndex":157,"researcher":22,"roles":4101,"affiliations":4102,"properties":4108},"6c9dcddb-b33e-4353-9a07-e21403c875af",[2981],[4103],{"id":22,"sortIndex":23,"affiliation":4104,"properties":22},{"id":4018,"createTime":4019,"updateTime":4020,"relativeEntities":4105,"slug":4022,"properties":4106,"entityType":200,"verifyStatus":384,"verifyTime":22,"verifyNote":22,"syncStatus":384,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":4107},{"VI":4025},{"title":4109},{"VI":4110},"J. W.A. 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Chromatographia. 2006, 63: 225-232. 10.1365/s10337-006-0737-6.\nStolker AAM, Niesing W, Hogendoorn EA, Versteegh JFM, Fuchs R, Brinkman UAT: Liquid chromatography with triple-quadrupole or quadrupole-time of flight mass spectrometry for screening and confirmation of residues of pharmaceuticals in water. Anal Bioanal Chem. 2004, 378: 955-963. 10.1007/s00216-003-2253-y.\nYe ZQ, Weinberg HS, Meyer MT: Trace analysis of trimethoprim and sulfonamide, macrolide, quinolone, and tetracycline antibiotics in chlorinated drinking water using liquid chromatography electrospray tandem mass spectrometry. Anal Chem. 2007, 79: 1135-1144. 10.1021/ac060972a.\nWen Q, Kong FY, Zheng HT, Yin JL, Cao DX, Ren YM, Wang GL: Simultaneous processes of electricity generation and ceftriaxone sodium degradation in an air-cathode single chamber microbial fuel cell. J Power Sources. 2011, 196: 2567-2572. 10.1016/j.jpowsour.2010.10.085.\nRozendal RA, Hamelers HVM, Rabaey K, Keller J, Buisman CJN: Towards practical implementation of bioelectrochemical wastewater treatment. Trends Biotechnol. 2008, 26: 450-459. 10.1016/j.tibtech.2008.04.008.\nLiu H, Ramnarayanan R, Logan BE: Production of electricity during wastewater treatment using a single chamber microbial fuel cell. Environ Sci Technol. 2004, 38: 2281-2285. 10.1021/es034923g.\nFeng Y, Wang X, Logan BE, Lee H: Brewery wastewater treatment using air-cathode microbial fuel cells. Appl Microbiol Biotechnol. 2008, 78: 873-880. 10.1007/s00253-008-1360-2.\nLu N, Zhou SG, Zhuang L, Zhang JT, Ni JR: Electricity generation from starch processing wastewater using microbial fuel cell technology. Biochem Eng J. 2009, 43: 246-251. 10.1016/j.bej.2008.10.005.\nMin B, Logan BE: Continuous electricity generation from domestic wastewater and organic substrates in a flat plate microbial fuel cell. Environ Sci Technol. 2004, 38: 5809-5814. 10.1021/es0491026.\nNasirahmadi S, Safekordi AA: Enhanced electricity generation from whey wastewater using combinational cathodic electron acceptor in a two-chamber microbial fuel cell. Int J Environ Sci Technol. 2012, 9: 473-478. 10.1007/s13762-012-0063-5.\nWu WG, Bai LL, Liu X, Tang ZM, Gu ZZ: Nanograss array boron-doped diamond electrode for enhanced electron transfer from Shewanella loihica PV-4. Electrochem Commun. 2011, 13: 872-874. 10.1016/j.elecom.2011.05.025.\nWen Q, Kong FY, Zheng HT, Cao DX, Ren YM, Yin JL: Electricity generation from synthetic penicillin wastewater in an air-cathode single chamber microbial fuel cell. Chem Eng J. 2011, 168: 572-576. 10.1016/j.cej.2011.01.025.\nPatil S, Harnisch F, Schröder U: Toxicity response of electroactive microbial biofilms-a decisive feature for potential biosensor and power source applications. ChemPhysChem. 2010, 11: 2834-2837. 10.1002/cphc.201000218.\nGoodman LS, Gilman A: Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 1985, McGraw-Hill Professional Publishing, New York\nDavies J, Davis BD: Misreading of ribonucleic acid code words induced by aminoglycoside antibiotics-effect of drug concentration. J Biol Chem. 1968, 243: 3312-3316.\nDavis BD: Mechanism of bactericidal action of aminoglycosides. Microbiol Rev. 1987, 51: 341-350.\nSutherland IW: The biofilm matrix-an immobilized but dynamic microbial environment. Trends Microbiol. 2001, 9: 222-227. 10.1016/S0966-842X(01)02012-1.\nSeifrtová M, Novaková L, Lino C, Pena A, Solich P: An overview of analytical methodologies for the determination of antibiotics in environmental waters. Anal Chim Acta. 2009, 649: 158-179. 10.1016/j.aca.2009.07.031.\nStein NE, Keesman KJ, Hamelers HVM, van Straten G: Kinetic models for detection of toxicity in a microbial fuel cell based biosensor. Biosens Bioelectron. 2011, 26: 3115-3120. 10.1016/j.bios.2010.11.049.\nCeri H, Olson ME, Stremick C, Read RR, Morck D, Buret A: The calgary biofilm device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol. 1999, 37: 1771-1776.\nKim M, Sik Hyun M, Gadd GM, Joo Kim H: A novel biomonitoring system using microbial fuel cells. J Environ Monit. 2007, 9: 1323-1328. 10.1039/b713114c.\nLesnik LK, Liu H: Establishing a core microbiome in acetate-fed microbial fuel cells. Appl Microbiol Biot. 2014, 98: 4187-4196. 10.1007/s00253-013-5502-9.\nBond DR, Lovley DR: Electricity production by Geobacter sulfurreducens attached to electrodes. Appl Environ Microbiol. 2003, 69: 1548-1555. 10.1128/AEM.69.3.1548-1555.2003.\nHolmes DE, Bond DR, O’Neill RA, Reimers CE, Tender LR, Lovley DR: Microbial communities associated with electrodes harvesting electricity from a variety of aquatic sediments. Microb Ecol. 2004, 48: 178-190. 10.1007/s00248-003-0004-4.\nKan JJ, Hsu L, Cheung ACM, Pirbazari M, Nealson KH: Current production by bacterial communities in microbial fuel cells enriched from wastewater sludge with different electron donors. Environ Sci Technol. 2011, 45: 1139-1146. 10.1021/es102645v.\nDíaz C, Baena S, Fardeau ML, Patel BKC:Aminiphilus circumscriptus gen. nov., sp. nov., an anaerobic amino-acid-degrading bacterium from an upflow anaerobic sludge reactor. Int J Syst Evol Microbiol. 2007, 57: 1914-1918. 10.1099/ijs.0.63614-0.\nSleat R, Mah RA, Robinson R:Acetoanaerobium noterae gen. nov., sp. nov.: an anaerobic bacterium that forms acetate from H2 and CO2. Int J Syst Evol Microbiol. 1985, 35: 10-15.\nParameswaran P, Zhang H, Torres CI, Rittmann BE, Krajmalnik-Brown R: Microbial community structure in a biofilm anode fed with a fermentable substrate: the significance of hydrogen scavengers. Biotechnol Bioeng. 2010, 105: 69-78. 10.1002/bit.22508.\nLiu H, Cheng SA, Logan BE: Production of electricity from acetate or butyrate using a single-chamber microbial fuel cell. Environ Sci Technol. 2005, 39: 658-662. 10.1021/es048927c.\nCatal T, Li K, Bermek H, Liu H: Electricity production from twelve monosaccharides using microbial fuel cells. J Power Sources. 2008, 175: 196-200. 10.1016/j.jpowsour.2007.09.083.\nCole JR, Wang Q, Cardenas E, Fish J, Chai B, Farris RJ, Kulam-Syed-Mohideen AS, McGarrell DM, Marsh T, Garrity GM, Tiedje JM: The ribosomal database project: improved alignments and new tools for rRNA analysis. Nucl Acids Res. 2009, 37: 141-145. 10.1093/nar/gkn879.\nEdgar RC: MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucl Acids Res. 2004, 32: 1792-1797. 10.1093/nar/gkh340.\nSchloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, Lesniewski RA, Oakley BB, Parks DH, Robinson CJ, Sahl JW, Stres B, Thallinger GG, Van Horn DJ, Weber CF: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol. 2009, 75: 7537-7541. 10.1128/AEM.01541-09.\nPark HS, Kim BH, Kim HS, Kim HJ, Kim GT, Kim M, Chang IS, Park YK, Chang HI: A novel electrochemically active and Fe(III)-reducing bacterium phylogenetically related to Clostridium butyricum isolated from a microbial fuel cell. Anaerobe. 2001, 7: 297-306. 10.1006/anae.2001.0399.",{"EN":4194,"VI":4195},"The release of antibiotics into aquatic environments has made the treatment of wastewater containing antibiotics a world-wide public health problem. The ability of microbial fuel cells (MFCs) to harvest electricity from organic waste and renewable biomass is attracting increased interest in wastewater treatment. In this paper we investigated the bioelectrochemical response of an electroactive mixed-culture biofilm in MFC to different tobramycin concentrations. The electroactive biofilms showed a high degree of robustness against tobramycin at the level of μg/L. The current generation responses of the biofilms were affected by the presence of tobramycin. The inhibition ratio of the MFC increased exponentially with the tobramycin concentrations in the range of 0.1-1.9 g/L. The bacterial communities of the biofilms vary with the concentrations of tobramycin, the equilibrium of which is critical for the stability of electroactive biofilms based-MFC. Experimental results demonstrate that the electroactive biofilm-based MFC is robust against antibiotics at the level of μg/L, but sensitive to changes in antibiotic concentration at the level of g/L. These results could provide significant information about the effects of antibiotics on the performance MFC as a waste-treatment technology.","Việc phát thải kháng sinh vào môi trường thủy sinh đã trở thành một vấn đề sức khỏe cộng đồng toàn cầu khi xử lý nước thải chứa kháng sinh. Khả năng của pin vi sinh vật (MFC) trong việc thu năng lượng từ chất thải hữu cơ và sinh khối tái tạo đang thu hút sự quan tâm ngày càng tăng trong việc xử lý nước thải. Trong bài báo này, chúng tôi đã điều tra phản ứng sinh điện hóa của một lớp biofilm hỗn hợp vi sinh vật điện hoạt trong MFC đối với các nồng độ tobramycin khác nhau. Các lớp biofilm điện hoạt cho thấy mức độ bền vững cao đối với tobramycin ở mức μg/L. Phản ứng sinh ra dòng điện của các lớp biofilm bị ảnh hưởng bởi sự hiện diện của tobramycin. Tỷ lệ ức chế của MFC tăng theo cấp số nhân với các nồng độ tobramycin trong khoảng 0,1-1,9 g/L. Các cộng đồng vi khuẩn của các lớp biofilm thay đổi theo nồng độ tobramycin, trong đó sự cân bằng là rất quan trọng cho sự ổn định của các lớp biofilm dựa trên MFC. Kết quả thí nghiệm cho thấy rằng MFC dựa trên lớp biofilm điện hoạt là bền vững trước kháng sinh ở mức μg/L, nhưng nhạy cảm với các biến đổi trong nồng độ kháng sinh ở mức g/L. Những kết quả này có thể cung cấp thông tin quan trọng về tác động của kháng sinh đối với hiệu suất của MFC như một công nghệ xử lý chất thải.",{"EN":4197,"VI":4198},"Impact of tobramycin on the performance of microbial fuel cell","Ảnh hưởng của tobramycin đối với hiệu suất của pin vi sinh vật",{"VOID":4200},"10.1186/s12934-014-0091-6",{"VI":4202},"tobramycin, pin vi sinh vật, biofilm điện hoạt, xử lý nước thải, sức khỏe cộng 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